PMID- 29852226
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 118
IP  - Pt A
DP  - 2018 Oct 15
TI  - Preparation and characterization of novel poly (vinyl alcohol)/collagen 
      double-network hydrogels.
PG  - 41-48
LID - S0141-8130(18)30884-5 [pii]
LID - 10.1016/j.ijbiomac.2018.05.200 [doi]
AB  - Hydrogels prepared by conventional methods show poor performance in many aspects. 
      Many double network (DN) hydrogels prepared by crosslinking agents have 
      disadvantages such as toxicity. In this work, we prepared novel DN hydrogels with 
      fish-originated collagen (Col) and poly (vinyl alcohol) (PVA), in which 
      self-assembly of collagen and self-crosslinking of PVA were achieved. Infrared 
      spectra indicated the existence of double network with chemical interactions 
      between Col and PVA. X-ray diffraction (XRD) patterns showed that characteristic 
      peak of freeze-thaw PVA in DN hydrogel was retained. Scanning electron microscope 
      (SEM) images before and after degradation and swelling property tests indicated 
      that the morphology of the hydrogel was a compact meshwork, which is consistent 
      with the high water-retention rate. The degradation rate of the DN hydrogels was 
      controlled by the ratio of Col and PVA. Compared with a pure collagen hydrogels, 
      the stress of DN hydrogels was greatly enhanced from 6 to 33 kPa at a strain of 
      40%. This study indicates that DN hydrogels prepared by Col and PVA are an ideal 
      biomaterial for tissue engineering.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Wang, Mingchao
AU  - Wang M
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Li, Jie
AU  - Li J
AD  - Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 
      264003, PR China.
FAU - Li, Wenjun
AU  - Li W
AD  - Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 
      264003, PR China.
FAU - Du, Zhenning
AU  - Du Z
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China. Electronic address: 
      zhenning.du@163.com.
FAU - Qin, Song
AU  - Qin S
AD  - Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 
      264003, PR China. Electronic address: sqin@yic.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20180528
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemical synthesis/*chemistry
MH  - Collagen/chemical synthesis/*chemistry
MH  - Fishes
MH  - Hydrogels/chemical synthesis/*chemistry
MH  - Polyvinyl Alcohol/chemical synthesis/*chemistry
MH  - Tissue Engineering/methods
OTO - NOTNLM
OT  - Collagen
OT  - Double-network
OT  - Hydrogel
OT  - Poly (vinyl alcohol)
OT  - Self-crosslink
EDAT- 2018/06/01 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/06/01 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/05/08 00:00 [revised]
PHST- 2018/05/26 00:00 [accepted]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/06/01 06:00 [entrez]
AID - S0141-8130(18)30884-5 [pii]
AID - 10.1016/j.ijbiomac.2018.05.200 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2018 Oct 15;118(Pt A):41-48. doi: 
      10.1016/j.ijbiomac.2018.05.200. Epub 2018 May 28.