PMID- 29854715
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20220410
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 2018
DP  - 2018
TI  - Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children.
PG  - 3870454
LID - 10.1155/2018/3870454 [doi]
LID - 3870454
AB  - INTRODUCTION: Interleukin-18 (IL-18) is a proinflammatory cytokine associated 
      with metabolic syndrome (MS). Nonalcoholic fatty liver disease (NAFLD) can be 
      recognized as a feature of MS. MATERIAL AND METHODS: Serum IL-18 concentration 
      was evaluated in serum of 108 obese children, determined with ELISA, and referred 
      to degree of liver steatosis in USG or total intrahepatic lipid content assessed 
      by magnetic resonance proton spectroscopy ((1)HMRS). RESULTS: Fatty liver was 
      confirmed in 89 children with USG and in 72 with (1)HMRS. IL-18 concentration 
      demonstrated significantly higher values in patients than in controls. 
      Significant correlations between IL-18 and ALT, GGT, triglycerides, hsCRP, and 
      the degree of liver steatosis were demonstrated. NAFLD children had significantly 
      higher level of IL-18, ALT, GGT, HOMA-IR, waist circumference, and total lipids 
      content in (1)HMRS than other obese children. IL-18 level was also significantly 
      higher in obese children with advanced liver steatosis. Measurement of serum 
      IL-18 showed ability to differentiate children with fatty liver from those 
      without steatosis. CONCLUSION: Elevated serum IL-18 concentration and its 
      correlation with hepatocyte injury, systemic inflammation, and degree of liver 
      steatosis support role in NAFLD pathomechanism. IL-18 can be considered to play a 
      role in predicting advanced liver steatosis and fatty liver in obese children.
FAU - Flisiak-Jackiewicz, Marta
AU  - Flisiak-Jackiewicz M
AUID- ORCID: 0000-0001-5157-8708
AD  - Department of Pediatrics, Gastroenterology and Allergology, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Bobrus-Chociej, Anna
AU  - Bobrus-Chociej A
AD  - Department of Pediatrics, Gastroenterology and Allergology, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Tarasow, Eugeniusz
AU  - Tarasow E
AD  - Department of Radiology, Medical University of Bialystok, Bialystok, Poland.
FAU - Wojtkowska, Malgorzata
AU  - Wojtkowska M
AD  - Department of Radiology, University Children Hospital, Bialystok, Poland.
FAU - Bialokoz-Kalinowska, Irena
AU  - Bialokoz-Kalinowska I
AD  - Lomza State University of Applied Sciences, Lomza, Poland.
FAU - Lebensztejn, Dariusz Marek
AU  - Lebensztejn DM
AD  - Department of Pediatrics, Gastroenterology and Allergology, Medical University of 
      Bialystok, Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20180426
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
RN  - 0 (Interleukin-18)
RN  - 0 (Triglycerides)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adolescent
MH  - Alanine Transaminase/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Interleukin-18/*blood/metabolism
MH  - Male
MH  - Non-alcoholic Fatty Liver Disease/*blood/complications/*diagnosis
MH  - Pediatric Obesity/*blood/complications
MH  - Predictive Value of Tests
MH  - Proton Magnetic Resonance Spectroscopy
MH  - Triglycerides/blood
MH  - Ultrasonography
MH  - Waist Circumference
MH  - gamma-Glutamyltransferase/metabolism
PMC - PMC5944203
EDAT- 2018/06/02 06:00
MHDA- 2019/02/12 06:00
PMCR- 2018/04/26
CRDT- 2018/06/02 06:00
PHST- 2018/02/03 00:00 [received]
PHST- 2018/04/05 00:00 [accepted]
PHST- 2018/06/02 06:00 [entrez]
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/04/26 00:00 [pmc-release]
AID - 10.1155/2018/3870454 [doi]
PST - epublish
SO  - Can J Gastroenterol Hepatol. 2018 Apr 26;2018:3870454. doi: 10.1155/2018/3870454. 
      eCollection 2018.