PMID- 29854816
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2018
DP  - 2018
TI  - Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate 
      with Metabolite Changes of Human Diabetes.
PG  - 1864865
LID - 10.1155/2018/1864865 [doi]
LID - 1864865
AB  - The New Zealand obese (NZO) mouse is a polygenic model for obesity and diabetes 
      with obese females and obese, diabetes-prone males, used to study traits of the 
      metabolic syndrome like type 2 diabetes mellitus (T2DM), obesity, and 
      dyslipidaemia. By using LC-MS/MS, we here examine the suitability of this model 
      to mirror tissue-specific changes in acylcarnitine (AC) and amino acid (AA) 
      species preceding T2DM which may reflect patterns investigated in human 
      metabolism. We observed high concentrations of fatty acid-derived ACs in 11 
      female mice, high abundance of branched-chain amino acid- (BCAA-) derived ACs in 
      6 male mice, and slight increases in BCAA-derived ACs in the remaining 6 males. 
      Principal component analysis (PCA) including all ACs and AAs confirmed our 
      hypothesis especially in plasma samples by clustering females, males with high 
      BCAA-derived ACs, and males with slight increases in BCAA-derived ACs. 
      Concentrations of insulin, blood glucose, NEFAs, and triacylglycerols (TAGs) 
      further supported the hypothesis of high BCAA-derived ACs being able to mirror 
      the onset of diabetic traits in male individuals. In conclusion, alterations in 
      AC and AA profiles overlap with observations from human studies indicating the 
      suitability of NZO mice to study metabolic changes preceding human T2DM.
FAU - Weiser, Anna
AU  - Weiser A
AUID- ORCID: 0000-0002-6433-024X
AD  - Nutrition Physiology, Technische Universitat Munchen, Gregor-Mendel-Str. 2, 85350 
      Freising, Germany.
FAU - Giesbertz, Pieter
AU  - Giesbertz P
AUID- ORCID: 0000-0001-7461-8602
AD  - Nutrition Physiology, Technische Universitat Munchen, Gregor-Mendel-Str. 2, 85350 
      Freising, Germany.
FAU - Daniel, Hannelore
AU  - Daniel H
AD  - Nutrition Physiology, Technische Universitat Munchen, Gregor-Mendel-Str. 2, 85350 
      Freising, Germany.
FAU - Spanier, Britta
AU  - Spanier B
AUID- ORCID: 0000-0001-7981-2017
AD  - Nutrition Physiology, Technische Universitat Munchen, Gregor-Mendel-Str. 2, 85350 
      Freising, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180426
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 0 (acylcarnitine)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Blood Glucose
MH  - Carnitine/*analogs & derivatives/blood/metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Hyperglycemia/blood/*metabolism
MH  - Insulin/blood
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Obese
MH  - Muscle, Skeletal/metabolism
MH  - Myocardium/metabolism
MH  - Obesity/blood/*metabolism
MH  - Triglycerides/blood
PMC - PMC5944288
EDAT- 2018/06/02 06:00
MHDA- 2018/10/12 06:00
PMCR- 2018/04/26
CRDT- 2018/06/02 06:00
PHST- 2017/11/22 00:00 [received]
PHST- 2018/02/28 00:00 [revised]
PHST- 2018/03/08 00:00 [accepted]
PHST- 2018/06/02 06:00 [entrez]
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/04/26 00:00 [pmc-release]
AID - 10.1155/2018/1864865 [doi]
PST - epublish
SO  - J Diabetes Res. 2018 Apr 26;2018:1864865. doi: 10.1155/2018/1864865. eCollection 
      2018.