PMID- 29854847
OWN - NLM
STAT- MEDLINE
DCOM- 20181011
LR  - 20181114
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2018
DP  - 2018
TI  - CD11c-Specific Deletion Reveals CREB as a Critical Regulator of DC Function 
      during the Germinal Center Response.
PG  - 8947230
LID - 10.1155/2018/8947230 [doi]
LID - 8947230
AB  - Dendritic cells (DCs) are crucial for the balance between immune response and 
      tolerance, but the molecular mechanism regulating development, differentiation, 
      and homeostasis are poorly understood. The transcriptional activator CREB is 
      involved in regulating different cells of the innate and adaptive immune system 
      and is a transcriptional regulator of development, survival, activation, or 
      proliferation in macrophages, dendritic cells, B cells, and T cells. To directly 
      examine the role of CREB in the regulation of DCs, the CREB gene was targeted for 
      deletion with a CD11c-cre transgene. The deletion of CREB in CD11c(+) cells did 
      not involve any developmental or systemic defects within DC populations. However, 
      CREB deficiency in CD11c(+) cells reduced germinal center (GC) B cells in steady 
      state, and immunization with NP-CGG resulted in a reduced formation of GCs, 
      paralleled by the reduced production of IgGs in sera of immunized mice. In 
      conclusion, we demonstrate that CREB expression in CD11c(+) cells enhances 
      germinal center responses, most likely by altering DC function, which might have 
      implications for autoimmune diseases that are associated with dysregulated GC 
      responses.
FAU - Ohl, Kim
AU  - Ohl K
AUID- ORCID: 0000-0002-3750-9527
AD  - Department of Pediatrics, Medical Faculty, RWTH Aachen, Aachen, Germany.
FAU - Schippers, Anastasia
AU  - Schippers A
AD  - Department of Pediatrics, Medical Faculty, RWTH Aachen, Aachen, Germany.
FAU - Tenbrock, Klaus
AU  - Tenbrock K
AUID- ORCID: 0000-0002-3566-227X
AD  - Department of Pediatrics, Medical Faculty, RWTH Aachen, Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180507
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (CD11c Antigen)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Autoimmune Diseases/*immunology
MH  - B-Lymphocytes/*physiology
MH  - CD11c Antigen/metabolism
MH  - Cells, Cultured
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*metabolism
MH  - Dendritic Cells/*immunology
MH  - Germinal Center/*immunology
MH  - Immunization
MH  - Immunoglobulin G/blood
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
PMC - PMC5964551
EDAT- 2018/06/02 06:00
MHDA- 2018/10/12 06:00
PMCR- 2018/05/07
CRDT- 2018/06/02 06:00
PHST- 2017/12/12 00:00 [received]
PHST- 2018/01/24 00:00 [revised]
PHST- 2018/03/11 00:00 [accepted]
PHST- 2018/06/02 06:00 [entrez]
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/05/07 00:00 [pmc-release]
AID - 10.1155/2018/8947230 [doi]
PST - epublish
SO  - J Immunol Res. 2018 May 7;2018:8947230. doi: 10.1155/2018/8947230. eCollection 
      2018.