PMID- 29855017
OWN - NLM
STAT- MEDLINE
DCOM- 20181224
LR  - 20181224
IS  - 1474-9092 (Electronic)
IS  - 1474-905X (Linking)
VI  - 17
IP  - 11
DP  - 2018 Nov 1
TI  - A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models.
PG  - 1599-1611
LID - 10.1039/c8pp00123e [doi]
AB  - Photodynamic therapy (PDT) represents a non-toxic and non-mutagenic antitumor 
      therapy. The photosensitizer's (PS) chemo-physical properties are essential for 
      the therapy, being responsible for the biological effects induced in the targeted 
      tissues. In this study, we present the synthesis and development of some 
      glycoconjugated porphyrins based on lectin-type receptor interaction. They were 
      tested in vitro for finally choosing the most effective chemical structure for an 
      optimum antitumor outcome. The most effective photosensitizer is substituted by 
      three diethylene glycol alpha-d-mannosyl groups. In vivo studies allow firstly the 
      determination of some characteristics of the biological processes triggered by 
      the initial photochemical activation. Secondly, they make it possible to improve 
      the therapeutic protocol in the function of the structural architecture of the 
      targeted tumor tissue.
FAU - Lupu, M
AU  - Lupu M
AUID- ORCID: 0000-0002-5586-6675
AD  - Institut Curie, Research Center, PSL Research University, CNRS, INSERM, UMR 9187, 
      U 1196, Chemistry, Modelling and Imaging for Biology (CMIB), Bat 110-112, Centre 
      Universitaire, F-91405 Orsay Cedex, France. carole.thomas@curie.fr and Universite 
      Paris Sud, Universite Paris-Saclay, CNRS, INSERM, UMR 9187, U 1196, Bat 110-112, 
      Centre Universitaire, F-91405 Orsay Cedex, France.
FAU - Maillard, Ph
AU  - Maillard P
AUID- ORCID: 0000-0002-0283-4207
AD  - Institut Curie, Research Center, PSL Research University, CNRS, INSERM, UMR 9187, 
      U 1196, Chemistry, Modelling and Imaging for Biology (CMIB), Bat 110-112, Centre 
      Universitaire, F-91405 Orsay Cedex, France. carole.thomas@curie.fr and Universite 
      Paris Sud, Universite Paris-Saclay, CNRS, INSERM, UMR 9187, U 1196, Bat 110-112, 
      Centre Universitaire, F-91405 Orsay Cedex, France.
FAU - Mispelter, J
AU  - Mispelter J
AUID- ORCID: 0000-0002-0122-0465
AD  - Institut Curie, Research Center, PSL Research University, CNRS, INSERM, UMR 9187, 
      U 1196, Chemistry, Modelling and Imaging for Biology (CMIB), Bat 110-112, Centre 
      Universitaire, F-91405 Orsay Cedex, France. carole.thomas@curie.fr and Universite 
      Paris Sud, Universite Paris-Saclay, CNRS, INSERM, UMR 9187, U 1196, Bat 110-112, 
      Centre Universitaire, F-91405 Orsay Cedex, France.
FAU - Poyer, F
AU  - Poyer F
AUID- ORCID: 0000-0002-5403-1326
AD  - Institut Curie, Research Center, PSL Research University, CNRS, INSERM, UMR 9187, 
      U 1196, Chemistry, Modelling and Imaging for Biology (CMIB), Bat 110-112, Centre 
      Universitaire, F-91405 Orsay Cedex, France. carole.thomas@curie.fr and Universite 
      Paris Sud, Universite Paris-Saclay, CNRS, INSERM, UMR 9187, U 1196, Bat 110-112, 
      Centre Universitaire, F-91405 Orsay Cedex, France.
FAU - Thomas, C D
AU  - Thomas CD
AUID- ORCID: 0000-0002-6935-1197
AD  - Institut Curie, Research Center, PSL Research University, CNRS, INSERM, UMR 9187, 
      U 1196, Chemistry, Modelling and Imaging for Biology (CMIB), Bat 110-112, Centre 
      Universitaire, F-91405 Orsay Cedex, France. carole.thomas@curie.fr and Universite 
      Paris Sud, Universite Paris-Saclay, CNRS, INSERM, UMR 9187, U 1196, Bat 110-112, 
      Centre Universitaire, F-91405 Orsay Cedex, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180601
PL  - England
TA  - Photochem Photobiol Sci
JT  - Photochemical & photobiological sciences : Official journal of the European 
      Photochemistry Association and the European Society for Photobiology
JID - 101124451
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*therapeutic use
MH  - *Disease Models, Animal
MH  - Mice
MH  - Neoplasms, Experimental/drug therapy
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/chemistry/*therapeutic use
EDAT- 2018/06/02 06:00
MHDA- 2018/12/26 06:00
CRDT- 2018/06/02 06:00
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2018/12/26 06:00 [medline]
PHST- 2018/06/02 06:00 [entrez]
AID - 10.1039/c8pp00123e [doi]
PST - ppublish
SO  - Photochem Photobiol Sci. 2018 Nov 1;17(11):1599-1611. doi: 10.1039/c8pp00123e. 
      Epub 2018 Jun 1.