PMID- 29855202
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20200306
IS  - 2158-0022 (Electronic)
IS  - 2158-0014 (Print)
IS  - 2158-0014 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb
TI  - Transient Patterns of Functional Dysconnectivity in Clinical High Risk and Early 
      Illness Schizophrenia Individuals Compared with Healthy Controls.
PG  - 60-76
LID - 10.1089/brain.2018.0579 [doi]
AB  - Schizophrenia shows abnormal dynamic functional network connectivity (dFNC), but 
      it is unclear whether these abnormalities are present early in the illness course 
      or precede illness onset in individuals at clinical high risk (CHR) for 
      psychosis. We examined dFNC from resting-state functional magnetic resonance 
      imaging data in CHR (n = 53), early illness schizophrenia (ESZ; n = 58), and 
      healthy control (HC; n = 70) individuals. We applied a sliding temporal window 
      approach capturing five distinct dFNC states. In ESZ patients, the likelihood of 
      transitioning from state 4, a state that exhibited greater cortical-subcortical 
      hyperconnectivity and also lacked typically observed anticorrelation between the 
      default mode network and other functional networks, to a hypoconnected state was 
      increased compared with HC and CHR groups. Furthermore, we investigated the 
      interaction of group and state on dFNC. Overall, HC individuals showed 
      significant changes of connectivity between states that were absent or altered in 
      ESZ patients and CHR individuals. Connectivity differences between groups were 
      identified primarily in two out of the five states, in particular, between HC and 
      ESZ groups. In summary, it appears that the interaction effect was mostly driven 
      by (1) dynamic connectivity changes in HC that were abnormal in CHR and ESZ 
      individuals and (2) the fact that dysconnectivity between groups was only present 
      in some states. These findings underscore the likelihood that abnormalities are 
      present not only in static FNC but also in dFNC, in individuals at CHR for 
      schizophrenia.
FAU - Mennigen, Eva
AU  - Mennigen E
AD  - 1 The Mind Research Network, Albuquerque, New Mexico.
AD  - 2 Department of Electrical and Computer Engineering, University of New Mexico, 
      Albuquerque, New Mexico.
FAU - Fryer, Susanna L
AU  - Fryer SL
AD  - 3 Department of Psychiatry, University of California, San Francisco, California.
AD  - 4 Mental Health Service, San Francisco VA Medical Center, San Francisco, 
      California.
FAU - Rashid, Barnaly
AU  - Rashid B
AD  - 1 The Mind Research Network, Albuquerque, New Mexico.
FAU - Damaraju, Eswar
AU  - Damaraju E
AD  - 1 The Mind Research Network, Albuquerque, New Mexico.
FAU - Du, Yuhui
AU  - Du Y
AD  - 1 The Mind Research Network, Albuquerque, New Mexico.
AD  - 5 School of Computer & Information Technology, Shanxi University, Taiyuan, China.
FAU - Loewy, Rachel L
AU  - Loewy RL
AD  - 3 Department of Psychiatry, University of California, San Francisco, California.
FAU - Stuart, Barbara K
AU  - Stuart BK
AD  - 3 Department of Psychiatry, University of California, San Francisco, California.
FAU - Calhoun, Vince D
AU  - Calhoun VD
AD  - 1 The Mind Research Network, Albuquerque, New Mexico.
AD  - 2 Department of Electrical and Computer Engineering, University of New Mexico, 
      Albuquerque, New Mexico.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - 3 Department of Psychiatry, University of California, San Francisco, California.
AD  - 4 Mental Health Service, San Francisco VA Medical Center, San Francisco, 
      California.
LA  - eng
GR  - P20 GM103472/GM/NIGMS NIH HHS/United States
GR  - P20 RR021938/RR/NCRR NIH HHS/United States
GR  - R01 EB020407/EB/NIBIB NIH HHS/United States
GR  - R01 MH076989/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180705
PL  - United States
TA  - Brain Connect
JT  - Brain connectivity
JID - 101550313
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Connectome/methods
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Psychotic Disorders/complications/diagnostic imaging/*physiopathology
MH  - Risk Factors
MH  - Schizophrenia/complications/diagnostic imaging/*physiopathology
MH  - Young Adult
PMC - PMC6390658
OTO - NOTNLM
OT  - clinical high risk
OT  - dysconnectivity
OT  - independent component analysis
OT  - schizophrenia
COIS- No competing financial interests exist.
EDAT- 2018/06/02 06:00
MHDA- 2019/08/30 06:00
PMCR- 2020/02/01
CRDT- 2018/06/02 06:00
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/06/02 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 10.1089/brain.2018.0579 [pii]
AID - 10.1089/brain.2018.0579 [doi]
PST - ppublish
SO  - Brain Connect. 2019 Feb;9(1):60-76. doi: 10.1089/brain.2018.0579. Epub 2018 Jul 
      5.