PMID- 29857236
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20181004
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 160
DP  - 2018 Sep 30
TI  - A network biology-based approach to evaluating the effect of environmental 
      contaminants on human interactome and diseases.
PG  - 316-327
LID - S0147-6513(18)30451-2 [pii]
LID - 10.1016/j.ecoenv.2018.05.065 [doi]
AB  - Environmental contaminant exposure can pose significant risks to human health. 
      Therefore, evaluating the impact of this exposure is of great importance; 
      however, it is often difficult because both the molecular mechanism of disease 
      and the mode of action of the contaminants are complex. We used network biology 
      techniques to quantitatively assess the impact of environmental contaminants on 
      the human interactome and diseases with a particular focus on seven major 
      contaminant categories: persistent organic pollutants (POPs), dioxins, polycyclic 
      aromatic hydrocarbons (PAHs), pesticides, perfluorochemicals (PFCs), metals, and 
      pharmaceutical and personal care products (PPCPs). We integrated publicly 
      available data on toxicogenomics, the diseasome, protein-protein interactions 
      (PPIs), and gene essentiality and found that a few contaminants were targeted to 
      many genes, and a few genes were targeted by many contaminants. The contaminant 
      targets were hub proteins in the human PPI network, whereas the target proteins 
      in most categories did not contain abundant essential proteins. Generally, 
      contaminant targets and disease-associated proteins were closely associated with 
      the PPI network, and the closeness of the associations depended on the disease 
      type and chemical category. Network biology techniques were used to identify 
      environmental contaminants with broad effects on the human interactome and 
      contaminant-sensitive biomarkers. Moreover, this method enabled us to quantify 
      the relationship between environmental contaminants and human diseases, which was 
      supported by epidemiological and experimental evidence. These methods and 
      findings have facilitated the elucidation of the complex relationship between 
      environmental exposure and adverse health outcomes.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Iida, M
AU  - Iida M
AD  - Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 
      Iizuka, Fukuoka 820-8502, Japan; Center for Marine Environmental Studies (CMES), 
      Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan. Electronic address: 
      iida.midori517@mail.kyutech.jp.
FAU - Takemoto, K
AU  - Takemoto K
AD  - Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 
      Iizuka, Fukuoka 820-8502, Japan. Electronic address: takemoto@bio.kyutech.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180529
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Cosmetics)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Metals)
RN  - 0 (Pesticides)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Cosmetics/toxicity
MH  - Dioxins/toxicity
MH  - Disease
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - Hydrocarbons, Fluorinated/toxicity
MH  - Metals/toxicity
MH  - Pesticides/toxicity
MH  - Polycyclic Aromatic Hydrocarbons/toxicity
MH  - Protein Interaction Maps
OTO - NOTNLM
OT  - Adverse outcomes
OT  - Environmental contaminants
OT  - Human interactome
OT  - Network biology
EDAT- 2018/06/02 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/06/02 06:00
PHST- 2018/01/05 00:00 [received]
PHST- 2018/05/07 00:00 [revised]
PHST- 2018/05/24 00:00 [accepted]
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/06/02 06:00 [entrez]
AID - S0147-6513(18)30451-2 [pii]
AID - 10.1016/j.ecoenv.2018.05.065 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2018 Sep 30;160:316-327. doi: 
      10.1016/j.ecoenv.2018.05.065. Epub 2018 May 29.