PMID- 29857326
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 61
DP  - 2018 Jul
TI  - Phenol and chlorinated phenols exhibit different apoptotic potential in human red 
      blood cells (in vitro study).
PG  - 95-101
LID - S1382-6689(18)30117-0 [pii]
LID - 10.1016/j.etap.2018.05.014 [doi]
AB  - Phenol and chlorinated phenols are widely spread in the environment and human 
      surrounding, which leads to a common environmental and occupational exposure of 
      humans to these substances. The aim of this study was to assess eryptotic changes 
      in human red blood cells treated with phenol, 2,4-dichlorophenol (2,4-DCP), 
      2,4,6-trichlorophenol (2,4,6-TCP) and pentachlorophenol (PCP). The erythrocytes 
      were incubated with phenols studied in the concentrations ranging from 1 to 
      100 mug/mL for 24 h or 48 h. The results of the study revealed that all compounds 
      studied caused phosphatidylserine translocation and increased cytosolic calcium 
      ions level in human erythrocytes. It was also noticed that phenol and 
      chlorophenols caused an increase in caspase-3 and calpain activation, which 
      confirmed that they were capable of inducing suicidal death of erythrocytes. The 
      results also revealed that PCP most strongly altered the parameters studied, 
      while phenol exhibited the weakest eryptotic potential in the incubated cells.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Michalowicz, Jaromir
AU  - Michalowicz J
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland. Electronic address: jaromir.michalowicz@biol.uni.lodz.pl.
FAU - Wluka, Anna
AU  - Wluka A
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland.
FAU - Cyrkler, Monika
AU  - Cyrkler M
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland.
FAU - Macczak, Aneta
AU  - Macczak A
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland.
FAU - Sicinska, Paulina
AU  - Sicinska P
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland.
FAU - Mokra, Katarzyna
AU  - Mokra K
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143 St., 90-001 Lodz, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20180523
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Phenols)
RN  - 0 (Phosphatidylserines)
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (Calpain)
RN  - EC 3.4.22.- (Caspase 3)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Apoptosis/drug effects
MH  - Calcium/metabolism
MH  - Calpain/metabolism
MH  - Caspase 3/metabolism
MH  - Erythrocytes/*drug effects/metabolism
MH  - Hemolysis/drug effects
MH  - Humans
MH  - Middle Aged
MH  - Phenols/*toxicity
MH  - Phosphatidylserines/metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Calpain
OT  - Caspase-3
OT  - Chlorophenols
OT  - Eryptosis
OT  - Phenol
OT  - Red blood cells
EDAT- 2018/06/02 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/06/02 06:00
PHST- 2017/11/15 00:00 [received]
PHST- 2018/04/20 00:00 [revised]
PHST- 2018/05/21 00:00 [accepted]
PHST- 2018/06/02 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/06/02 06:00 [entrez]
AID - S1382-6689(18)30117-0 [pii]
AID - 10.1016/j.etap.2018.05.014 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2018 Jul;61:95-101. doi: 10.1016/j.etap.2018.05.014. 
      Epub 2018 May 23.