PMID- 29858545
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20240328
IS  - 2162-3279 (Electronic)
VI  - 8
IP  - 7
DP  - 2018 Jul
TI  - Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A 
      systematic review.
PG  - e01009
LID - 10.1002/brb3.1009 [doi]
LID - e01009
AB  - INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has an important role in 
      the neurogenesis and neuroplasticity of the brain. This systematic review was 
      designed to examine the association between BDNF Val66Met (rs6265) polymorphism 
      and four cognitive domains-attention and concentration, executive function, 
      verbal fluency, and memory, respectively. METHODOLOGY: Primary literature search 
      was performed using search engines such as PubMed and Scopus. Observational 
      studies that evaluated the neurocognitive performances in relation to BDNF 
      polymorphism within human subjects were included in this review, while animal 
      studies, overlapping studies, and meta-analysis were excluded. RESULTS: Forty of 
      82 reviewed studies (48.8%) reported an association between Val66Met polymorphism 
      and neurocognitive domains. The proportion of the studies showing positive 
      findings in cognitive performances between Val/Val homozygotes and Met carriers 
      was comparable, at 30.5% and 18.3%, respectively. The highest percentage of 
      positive association between Val66Met polymorphism and neurocognition was 
      reported under the memory domain, with 26 of 63 studies (41.3%), followed by 18 
      of 47 studies (38.3%) under the executive function domain and four of 23 studies 
      (17.4%) under the attention and concentration domain. There were no studies 
      showing an association between Val66Met polymorphism and verbal fluency. In 
      particular, Val/Val homozygotes performed better in tasks related to the memory 
      domain, while Met carriers performed better in terms of executive function, in 
      both healthy individuals and clinical populations. CONCLUSION: While numerous 
      studies report an association between Val66Met polymorphism and neurocognitive 
      changes in executive function and memory domains, the effect of Met allele has 
      not been clearly established.
CI  - (c) 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
FAU - Toh, Yi Long
AU  - Toh YL
AUID- ORCID: 0000-0003-2997-555X
AD  - Department of Pharmacy, Faculty of Science, National University of Singapore, 
      Singapore, Singapore.
FAU - Ng, Terence
AU  - Ng T
AD  - Department of Pharmacy, Faculty of Science, National University of Singapore, 
      Singapore, Singapore.
FAU - Tan, Megan
AU  - Tan M
AD  - Department of Pharmacy, Faculty of Science, National University of Singapore, 
      Singapore, Singapore.
FAU - Tan, Azrina
AU  - Tan A
AD  - Department of Pharmacy, Faculty of Science, National University of Singapore, 
      Singapore, Singapore.
FAU - Chan, Alexandre
AU  - Chan A
AD  - Department of Pharmacy, Faculty of Science, National University of Singapore, 
      Singapore, Singapore.
AD  - Department of Pharmacy, National Cancer Centre Singapore, Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180601
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Cognition Disorders/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
PMC - PMC6043712
OTO - NOTNLM
OT  - attention
OT  - brain-derived neurotrophic factor
OT  - executive control
OT  - memory
OT  - neuroprotection
EDAT- 2018/06/03 06:00
MHDA- 2019/05/08 06:00
PMCR- 2018/06/01
CRDT- 2018/06/03 06:00
PHST- 2017/07/30 00:00 [received]
PHST- 2018/04/08 00:00 [revised]
PHST- 2018/04/15 00:00 [accepted]
PHST- 2018/06/03 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2018/06/03 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - BRB31009 [pii]
AID - 10.1002/brb3.1009 [doi]
PST - ppublish
SO  - Brain Behav. 2018 Jul;8(7):e01009. doi: 10.1002/brb3.1009. Epub 2018 Jun 1.