PMID- 29858712
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181114
IS  - 1573-5168 (Electronic)
IS  - 0920-1742 (Linking)
VI  - 44
IP  - 5
DP  - 2018 Oct
TI  - Oxidative stress and antioxidant responses in juvenile Brazilian flounder 
      Paralichthys orbignyanus exposed to sublethal levels of nitrite.
PG  - 1349-1362
LID - 10.1007/s10695-018-0526-9 [doi]
AB  - This study evaluated the effects of short-term exposure to sublethal levels of 
      nitrite on oxidative stress parameters and histology of juvenile Brazilian 
      flounder Paralichthys orbignyanus. An assessment of fish recovery was also 
      performed. Fish were exposed to 0.08 (control), 5.72, 10.43, and 15.27 NO(2)-N 
      mg L(-1) for 10 days followed by the same recovery time. Gill, liver, and muscle 
      samples were collected after 1, 5, and 10 days of exposure and after recovery for 
      the measurement of antioxidant capacity against peroxyl radicals (ACAP), 
      glutathione-S-transferase (GST) activity, content of non-protein (NPSH) and 
      protein thiols (PSH), and lipid peroxidation levels by thiobarbituric 
      acid-reactive substances (TBARS) content. Nitrite exposure induced alterations 
      which compromised the overall antioxidant system (reduced ACAP and GST activity) 
      and enhanced oxidative damage in lipids and proteins. Increases in GST activity 
      and NPSH and PSH contents were also demonstrated. The recovery period allowed for 
      resumption of basal levels for all (treatment 5.72 NO(2)-N mg L(-1)) or some of 
      the evaluated parameters (other treatments). In conclusion, exposure to nitrite 
      concentrations from 5.72 to 15.27 NO(2)-N mg L(-1) induced oxidative stress and 
      antioxidant responses in juvenile Brazilian flounder. The 10-day recovery period 
      was sufficient for a complete resumption of basal physiological condition of fish 
      exposed to concentrations of up to 5.72 NO(2)-N mg L(-1).
FAU - Maltez, Lucas Campos
AU  - Maltez LC
AD  - Laboratorio de Aquacultura Continental, Instituto de Oceanografia, Universidade 
      Federal do Rio Grande - FURG, Rio Grande, RS, 96203-900, Brazil.
FAU - Barbas, Luis Andre Luz
AU  - Barbas LAL
AD  - Laboratorio de Aquacultura de Especies Tropicais, Instituto Federal de Educacao 
      Ciencia e Tecnologia do Para - Campus Castanhal, Castanhal, PA, Brazil.
FAU - Nitz, Lilian Fiori
AU  - Nitz LF
AD  - Laboratorio de Aquacultura Continental, Instituto de Oceanografia, Universidade 
      Federal do Rio Grande - FURG, Rio Grande, RS, 96203-900, Brazil.
FAU - Pellegrin, Lucas
AU  - Pellegrin L
AD  - Laboratorio de Aquacultura Continental, Instituto de Oceanografia, Universidade 
      Federal do Rio Grande - FURG, Rio Grande, RS, 96203-900, Brazil.
FAU - Okamoto, Marcelo Hideo
AU  - Okamoto MH
AD  - Laboratorio de Piscicultura Estuarina e Marinha, Instituto de Oceanografia, 
      Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil.
FAU - Sampaio, Luis Andre
AU  - Sampaio LA
AD  - Laboratorio de Piscicultura Estuarina e Marinha, Instituto de Oceanografia, 
      Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil.
FAU - Monserrat, Jose Maria
AU  - Monserrat JM
AD  - Laboratorio de Bioquimica Funcional de Organismos Aquaticos, Instituto de 
      Oceanografia, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil.
FAU - Garcia, Luciano
AU  - Garcia L
AD  - Laboratorio de Aquacultura Continental, Instituto de Oceanografia, Universidade 
      Federal do Rio Grande - FURG, Rio Grande, RS, 96203-900, Brazil. 
      garcia_log@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180601
PL  - Netherlands
TA  - Fish Physiol Biochem
JT  - Fish physiology and biochemistry
JID - 100955049
RN  - 0 (Antioxidants)
RN  - 0 (Nitrites)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Flounder/*physiology
MH  - Nitrites/administration & dosage/*toxicity
MH  - Oxidative Stress/*drug effects
MH  - Water Pollutants, Chemical/administration & dosage/toxicity
OTO - NOTNLM
OT  - Fish recovery
OT  - Lipid peroxidation
OT  - Nitrogen compound
OT  - Thiol groups
OT  - Toxicity
EDAT- 2018/06/03 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/06/03 06:00
PHST- 2018/01/14 00:00 [received]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/06/03 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/06/03 06:00 [entrez]
AID - 10.1007/s10695-018-0526-9 [pii]
AID - 10.1007/s10695-018-0526-9 [doi]
PST - ppublish
SO  - Fish Physiol Biochem. 2018 Oct;44(5):1349-1362. doi: 10.1007/s10695-018-0526-9. 
      Epub 2018 Jun 1.