PMID- 29859931
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 681
DP  - 2018 Aug 10
TI  - Serum BDNF levels in patients with opioid dependence during the early withdrawal 
      period: A case control study.
PG  - 100-104
LID - S0304-3940(18)30399-9 [pii]
LID - 10.1016/j.neulet.2018.05.048 [doi]
AB  - BACKGROUND AND AIMS: Brain-Derived Neurotrophic Factor (BDNF), a neuropeptide 
      important for neural growth and differentiation has been explored in patients 
      with opioid dependence. We aimed to compare the serum BDNF levels in patients 
      with opioid dependence with age and gender matched controls, and to assess change 
      in BDNF levels during initial withdrawal period. METHODS: Thirty cases with a 
      diagnosis of opioid dependence were compared to forty healthy controls. BDNF 
      levels were measured at inclusion for all participants. Additionally, BDNF levels 
      were measured in patients with opioid dependence after 10 days of inpatient 
      detoxification. RESULTS: There were no group differences in BDNF levels between 
      cases and controls for day 1 BDNF levels. Also, there was no significant 
      difference observed in the BDNF levels in patients at day 1 and 10 of inpatient 
      detoxification. BDNF levels did not correlate with severity of nicotine 
      dependence, age of the cases or duration of opioid dependence. CONCLUSION: The 
      results from the study provide further insights into the relationship of BDNF 
      levels and opioid dependence.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sarkar, Siddharth
AU  - Sarkar S
AD  - National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical 
      Sciences (AIIMS), New Delhi, 110029, India. Electronic address: 
      siddharthsarkar@aiims.edu.
FAU - Jain, Raka
AU  - Jain R
AD  - National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical 
      Sciences (AIIMS), New Delhi, 110029, India.
FAU - Kethawath, Shanti M
AU  - Kethawath SM
AD  - National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical 
      Sciences (AIIMS), New Delhi, 110029, India.
FAU - Gupta, Rishi
AU  - Gupta R
AD  - National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical 
      Sciences (AIIMS), New Delhi, 110029, India.
FAU - Kumar, Mukesh
AU  - Kumar M
AD  - National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical 
      Sciences (AIIMS), New Delhi, 110029, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180531
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Opioid-Related Disorders/*blood/*diagnosis
MH  - Substance Withdrawal Syndrome/*blood/*diagnosis
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Neuropeptide
OT  - Opioid dependence
OT  - Withdrawal
EDAT- 2018/06/04 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/06/04 06:00
PHST- 2018/03/31 00:00 [received]
PHST- 2018/05/26 00:00 [revised]
PHST- 2018/05/30 00:00 [accepted]
PHST- 2018/06/04 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/06/04 06:00 [entrez]
AID - S0304-3940(18)30399-9 [pii]
AID - 10.1016/j.neulet.2018.05.048 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Aug 10;681:100-104. doi: 10.1016/j.neulet.2018.05.048. Epub 
      2018 May 31.