PMID- 29860190
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20191014
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 48
DP  - 2018 Aug
TI  - Polysomnographic findings in restless legs syndrome (RLS) patients with severe 
      augmentation.
PG  - 79-85
LID - S1389-9457(18)30161-8 [pii]
LID - 10.1016/j.sleep.2018.04.010 [doi]
AB  - BACKGROUND AND OBJECTIVES: Augmentation can occur frequently in restless legs 
      syndrome (RLS) patients treated with dopaminergic agents. Video-polysomnographic 
      (PSG) data from augmented RLS patients are scant. The aim of this study was to 
      evaluate PSG findings in augmented RLS patients and compare them with those of 
      non-augmented RLS patients. PATIENTS AND METHODS: Valid PSG data were analyzed 
      from 99 augmented and 84 non-augmented RLS inpatients who underwent one night 
      PSG. RESULTS: Both patient groups showed a high subjective burden of RLS 
      symptoms. The mean scores on the International RLS Study Group Rating Scale 
      (IRLS) were significantly higher in the group with augmentation than in the group 
      without. The periodic leg movement index (PLMI) was increased in both groups, 
      mostly on account of the PLM in wakefulness (PLMW). Both groups presented a 
      reduced sleep efficiency and an increased sleep latency. The levodopa equivalent 
      dose (LED) was significantly higher in the augmented group. CONCLUSIONS: Our 
      study confirms that RLS patients with augmentation have disturbed sleep due to 
      high amount of leg movements and fragmented sleep. Overall, however, 
      polysomnographic characteristics were not different between insufficiently 
      treated RLS and severely augmented RLS patients, implying that augmentation could 
      represent a severe form of RLS and not a different phenomenon.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Steinke, Sophia Stephanie
AU  - Steinke SS
AD  - Department of Neurosurgery, University Medical Center, Gottingen, Germany; 
      Paracelsus Elena Hospital, Kassel, Germany.
FAU - Trenkwalder, Claudia
AU  - Trenkwalder C
AD  - Department of Neurosurgery, University Medical Center, Gottingen, Germany; 
      Paracelsus Elena Hospital, Kassel, Germany.
FAU - Zimmermann, Johannes
AU  - Zimmermann J
AD  - Psychologische Hochschule, Berlin, Germany.
FAU - Sixel-Doring, Friederike
AU  - Sixel-Doring F
AD  - Paracelsus Elena Hospital, Kassel, Germany; Department of Neurology, Philips 
      University, Marburg, Germany.
FAU - Muntean, Maria-Lucia
AU  - Muntean ML
AD  - Paracelsus Elena Hospital, Kassel, Germany. Electronic address: 
      luciamuntean@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180505
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (Dopamine Agents)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Dopamine Agents/*therapeutic use
MH  - Female
MH  - Humans
MH  - Levodopa/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Polysomnography/*methods
MH  - Restless Legs Syndrome/*drug therapy
MH  - *Severity of Illness Index
MH  - Wakefulness/physiology
OTO - NOTNLM
OT  - Augmentation
OT  - Polysomnography
OT  - Restless legs syndrome
EDAT- 2018/06/04 06:00
MHDA- 2019/10/15 06:00
CRDT- 2018/06/04 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/04/22 00:00 [revised]
PHST- 2018/04/25 00:00 [accepted]
PHST- 2018/06/04 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2018/06/04 06:00 [entrez]
AID - S1389-9457(18)30161-8 [pii]
AID - 10.1016/j.sleep.2018.04.010 [doi]
PST - ppublish
SO  - Sleep Med. 2018 Aug;48:79-85. doi: 10.1016/j.sleep.2018.04.010. Epub 2018 May 5.