PMID- 29860211 OWN - NLM STAT- MEDLINE DCOM- 20190906 LR - 20190906 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 165 DP - 2018 Aug TI - Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway. PG - 387-399 LID - S0013-9351(18)30226-3 [pii] LID - 10.1016/j.envres.2018.04.026 [doi] AB - In the present study, blood clinical-chemical parameters (BCCPs) were analysed in 20 female and 18 male Svalbard polar bears (Ursus maritimus) captured in spring 2007. The aim was to study how age, body condition (BC), biometrics, plasma lipid content and geographical location may confound the relationship between persistent organic pollutants (POPs) including PCBs, HCB, chlordanes, DDTs, HCHs, mirex and OH-PCBs and the concentrations of 12 specific BCCPs (hematocrit [HCT], hemoglobin [HB], aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT], gamma-glutamyltransferase [GGT], creatine kinase [CK], triglycerides [TG], cholesterol [CHOL], high-density lipoprotein [HDL], creatinine (CREA], urea, potassium (K]), and to investigate if any of these BCCPs may be applied as potential biomarkers for POP exposure in polar bears. Initial PCA and O-PLS modelling showed that age, lipids, BC and geographical location (longitude and latitude) were important parameters explaining BCCPs in females. Following subsequent partial correlation analyses correcting for age and lipids, multiple POPs in females were still significantly correlated with HCT and HDL (all p < 0.05). In males, age, BM, BC and longitude were important parameters explaining BCCPs. Following partial correlation analyses correcting for age, biometrics, lipids and longitude in males, multiple POPs were significantly correlated with HCT, ASAT, GGT and CHOL (all p < 0.05). In conclusion, several confounding parameters has to be taken into account when studying the relations between BCCPs and POPs in polar bears. When correcting for these, in particular HCT may be used as a simple cost-efficient biomarker of POP exposure in polar bears. Furthermore, decreasing HDL concentrations and increasing CHOL concentration with increasing POP concentrations may indicate responses related to increased risk of cardiovascular disease. We therefore suggest to further study POP exposure and lipidome response to increase knowledge of the risk of cardiometabolic syndrome in polar bears. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Ciesielski, Tomasz Maciej AU - Ciesielski TM AD - Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. Electronic address: tomasz.m.ciesielski@ntnu.no. FAU - Sonne, Christian AU - Sonne C AD - Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, Faculty of Science and Technology, Frederiksborgvej 399, POBox 358, DK-4000 Roskilde, Denmark. Electronic address: cs@bios.au.dk. FAU - Ormbostad, Ingunn AU - Ormbostad I AD - Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. Electronic address: ingunnormbostad@gmail.com. FAU - Aars, Jon AU - Aars J AD - Norwegian Polar Institute, Fram Centre, NO-9296 Tromso, Norway. Electronic address: jon.aars@npolar.no. FAU - Lie, Elisabeth AU - Lie E AD - Norwegian Institute for Water research (NIVA), Gaustadalleen 21, 0349 Oslo, Norway. Electronic address: elisabeth.lie@niva.no. FAU - Bytingsvik, Jenny AU - Bytingsvik J AD - Akvaplan-niva AS, Fram Centre - High North Research Centre for Climate and the Environment, Hjalmar Johansens Gate 14, 9007 Tromso, Norway. Electronic address: jby@akvaplan.niva.no. FAU - Jenssen, Bjorn Munro AU - Jenssen BM AD - Department of Biology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway; Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, Faculty of Science and Technology, Frederiksborgvej 399, POBox 358, DK-4000 Roskilde, Denmark; Department of Arctic Technology, The University Centre in Svarbard, POBox 156, NO-9171 Longyearbyen, Norway. Electronic address: bjorn.munro.jenssen@ntnu.no. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180531 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Biomarkers) RN - 0 (Environmental Pollutants) RN - 12789-03-6 (Chlordan) RN - CIW5S16655 (DDT) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Animals MH - Biomarkers/blood MH - Chlordan/blood MH - DDT/blood MH - Environmental Pollutants/*blood MH - Female MH - Male MH - Polychlorinated Biphenyls/blood MH - Svalbard MH - Ursidae/*blood OTO - NOTNLM OT - BCCPs OT - POPs OT - Polar bears EDAT- 2018/06/04 06:00 MHDA- 2019/09/07 06:00 CRDT- 2018/06/04 06:00 PHST- 2018/01/16 00:00 [received] PHST- 2018/04/11 00:00 [revised] PHST- 2018/04/23 00:00 [accepted] PHST- 2018/06/04 06:00 [pubmed] PHST- 2019/09/07 06:00 [medline] PHST- 2018/06/04 06:00 [entrez] AID - S0013-9351(18)30226-3 [pii] AID - 10.1016/j.envres.2018.04.026 [doi] PST - ppublish SO - Environ Res. 2018 Aug;165:387-399. doi: 10.1016/j.envres.2018.04.026. Epub 2018 May 31.