PMID- 29861070
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20221207
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 331
DP  - 2018 Sep
TI  - MFG-E8 inhibits Abeta-induced microglial production of cathelicidin-related 
      antimicrobial peptide: A suitable target against Alzheimer's disease.
PG  - 59-66
LID - S0008-8749(18)30219-3 [pii]
LID - 10.1016/j.cellimm.2018.05.008 [doi]
AB  - Neuroinflammation plays a pivotal role in the incidence and progression of 
      Alzheimer's disease (AD). Cathelicidin-related antimicrobial peptide (CRAMP) is 
      critically involved in the innate neuronal responses of chronic neuroinflammation 
      in AD and thus plays a key role in the disease. Here, we show that Abeta42 induced 
      microglial production of CRAMP, which was effectively inhibited by milk-fat 
      globule-epidermal growth factor 8 (MFG-E8). Production of CRAMP was associated 
      with activation of ERK1/2, p38 and phospho-P65-NF-kB upregulation. Additionally, 
      the phosphorylation of these signaling proteins was also reversed by MFG-E8. 
      Pre-incubation with signaling inhibitors confirmed that MFG-E8 has a regulatory 
      role on CRAMP through MAPK and NF-kB signaling pathways. MFG-E8 treatment may 
      thus be a potential pharmacotherapy for chronic inflammation in AD.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Xu, Xiaotian
AU  - Xu X
AD  - Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological 
      Diseases, Department of Neurology, National Key Clinical Department and Key 
      Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province 510080, People's Republic of China.
FAU - Cai, Xiaoying
AU  - Cai X
AD  - Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen 
      University, No. 58 Zhongshan 2nd Road, Guangzhou 510080, People's Republic of 
      China.
FAU - Zhu, Yingting
AU  - Zhu Y
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, People's Republic of China.
FAU - He, Wen
AU  - He W
AD  - Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological 
      Diseases, Department of Neurology, National Key Clinical Department and Key 
      Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province 510080, People's Republic of China.
FAU - Wu, Qi
AU  - Wu Q
AD  - Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological 
      Diseases, Department of Neurology, National Key Clinical Department and Key 
      Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province 510080, People's Republic of China.
FAU - Shi, Xiaolei
AU  - Shi X
AD  - Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 
      Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada; Department of Neurology, The First 
      Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      Province 241000, People's Republic of China. Electronic address: 
      shixiaolei05@gmail.com.
FAU - Fang, Yannan
AU  - Fang Y
AD  - Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological 
      Diseases, Department of Neurology, National Key Clinical Department and Key 
      Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province 510080, People's Republic of China. Electronic 
      address: fyn2012@126.com.
FAU - Pei, Zhong
AU  - Pei Z
AD  - Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological 
      Diseases, Department of Neurology, National Key Clinical Department and Key 
      Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong Province 510080, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180524
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Antigens, Surface)
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Mfge8 protein, mouse)
RN  - 0 (Milk Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - 0 (Cathelicidins)
SB  - IM
MH  - Alzheimer Disease/drug therapy/genetics/metabolism
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Antigens, Surface/*pharmacology
MH  - Antimicrobial Cationic Peptides/*antagonists & inhibitors/genetics/metabolism
MH  - Cells, Cultured
MH  - Gene Expression/drug effects
MH  - Inflammation/drug therapy/genetics/metabolism
MH  - Mice, Inbred C57BL
MH  - Microglia/*drug effects/metabolism
MH  - Milk Proteins/*pharmacology
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Peptide Fragments/*toxicity
MH  - Phosphorylation/drug effects
MH  - Signal Transduction/drug effects
MH  - Cathelicidins
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Abeta42
OT  - CRAMP
OT  - MFG-E8
OT  - Microglia
EDAT- 2018/06/05 06:00
MHDA- 2019/07/02 06:00
CRDT- 2018/06/05 06:00
PHST- 2018/01/13 00:00 [received]
PHST- 2018/05/18 00:00 [revised]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/06/05 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2018/06/05 06:00 [entrez]
AID - S0008-8749(18)30219-3 [pii]
AID - 10.1016/j.cellimm.2018.05.008 [doi]
PST - ppublish
SO  - Cell Immunol. 2018 Sep;331:59-66. doi: 10.1016/j.cellimm.2018.05.008. Epub 2018 
      May 24.