PMID- 29861423
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2311-553X (Electronic)
IS  - 2311-553X (Linking)
VI  - 1
IP  - 3
DP  - 2015 Sep 30
TI  - Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific 
      Targets and Are Processed to Small RNA Species.
PG  - 170-191
LID - 10.3390/ncrna1030170 [doi]
AB  - The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two 
      non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of 
      NK/T cell lines and primary cells and Northern blotting of EBV-infected cell 
      lines and primary tumors revealed processing of EBER1 to short 5'-derived RNAs of 
      approximately 23, 52 and 70 nt (EBER123, EBER152, and EBER170) and of EBER2 to 3' 
      fragments. The biogenesis of these species is independent of Dicer, and EBER123 
      does not act like a miRNA OPEN ACCESS Non-Coding RNA 2015, 1 171 to target its 
      complementary sequence. EBER1, EBER2 and EBER123 were bound by the lupus antigen 
      (La), a nuclear and cytoplasmic protein that facilitates RNAi. Consistent with 
      this, the EBERs affect regulation of interleukin 1alpha (IL1alpha) and RAC1 reporters 
      harboring miR target sequences, targets of miR-142-3p. However, the EBERs have no 
      effect upon another target of miR-142-3p, ADCY9, nor on TOMM22, a target of 
      ebv-miR-BART16, indicative of selective modulation of gene expression by the 
      EBERs.
FAU - Alles, Julia
AU  - Alles J
AD  - Institute of Virology, Saarland University Medical School, Kirrbergerstrasse, 
      Haus 47, Homburg/Saar D-66421, Germany. ju.al@mx.uni-saarland.de.
FAU - Hasler, Daniele
AU  - Hasler D
AD  - Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of 
      Regensburg, Universitatsstrasse 31, Regensburg D-93053, Germany. 
      Daniele.Hasler@vkl.uni-regensburg.de.
FAU - Kazmi, Syed Mohammad Ali
AU  - Kazmi SMA
AD  - College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 
      G12 8QQ, UK. alikazmi39@gmail.com.
FAU - Tesson, Mathias
AU  - Tesson M
AD  - College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 
      G12 8QQ, UK. Mathias.Tesson@glasgow.ac.uk.
FAU - Hamilton, Andrew
AU  - Hamilton A
AD  - College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 
      G12 8QQ, UK. Andrew.Hamilton@glasgow.ac.uk.
FAU - Schlegel, Linda
AU  - Schlegel L
AD  - Institute of Virology, Saarland University Medical School, Kirrbergerstrasse, 
      Haus 47, Homburg/Saar D-66421, Germany. lindaschlegel@gmx.de.
FAU - Marx, Stefanie
AU  - Marx S
AD  - Institute of Virology, Saarland University Medical School, Kirrbergerstrasse, 
      Haus 47, Homburg/Saar D-66421, Germany. stefanie.marx@uks.eu.
FAU - Eichner, Norbert
AU  - Eichner N
AD  - Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of 
      Regensburg, Universitatsstrasse 31, Regensburg D-93053, Germany. 
      Norbert.Eichner@vkl.uni-regensburg.de.
FAU - Reinhardt, Richard
AU  - Reinhardt R
AD  - Max Planck Genome Centre Cologne, Carl-von-Linne-Weg 10, Cologne D-50829, 
      Germany. reinhardt@mpipz.mpg.de.
FAU - Meister, Gunter
AU  - Meister G
AD  - Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of 
      Regensburg, Universitatsstrasse 31, Regensburg D-93053, Germany. 
      Gunter.Meister@vkl.uni-regensburg.de.
FAU - Wilson, Joanna B
AU  - Wilson JB
AD  - College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 
      G12 8QQ, UK. joanna.wilson@glasgow.ac.uk.
FAU - Grasser, Friedrich A
AU  - Grasser FA
AD  - Institute of Virology, Saarland University Medical School, Kirrbergerstrasse, 
      Haus 47, Homburg/Saar D-66421, Germany. graesser@uks.eu.
LA  - eng
PT  - Journal Article
DEP - 20150930
PL  - Switzerland
TA  - Noncoding RNA
JT  - Non-coding RNA
JID - 101652294
PMC - PMC5932547
OTO - NOTNLM
OT  - ADCY9
OT  - DICER
OT  - EBER
OT  - EBV
OT  - Epstein-Barr virus
OT  - IL1A
OT  - La
OT  - Lupus antigen
OT  - RAC1
OT  - TOMM22
OT  - ebv-miR-BART16
OT  - hsa-miR-142
OT  - microRNA
COIS- The authors declare no conflict of interest.
EDAT- 2015/09/30 00:00
MHDA- 2015/09/30 00:01
PMCR- 2015/09/30
CRDT- 2018/06/05 06:00
PHST- 2015/08/11 00:00 [received]
PHST- 2015/09/22 00:00 [revised]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2018/06/05 06:00 [entrez]
PHST- 2015/09/30 00:00 [pubmed]
PHST- 2015/09/30 00:01 [medline]
PHST- 2015/09/30 00:00 [pmc-release]
AID - ncrna1030170 [pii]
AID - ncrna-01-00170 [pii]
AID - 10.3390/ncrna1030170 [doi]
PST - epublish
SO  - Noncoding RNA. 2015 Sep 30;1(3):170-191. doi: 10.3390/ncrna1030170.