PMID- 2986183
OWN - NLM
STAT- MEDLINE
DCOM- 19850614
LR  - 20190919
IS  - 0031-6989 (Print)
IS  - 0031-6989 (Linking)
VI  - 17
IP  - 2
DP  - 1985 Feb
TI  - Intracerebroventricular saline treatment elevates the pain threshold. Is this 
      phenomenon mediated by peripheral opiate receptors?
PG  - 177-87
AB  - Intracerebroventricular (i.c.v.) saline treatment of unanaesthetized mice 
      resulted in moderate but well detectable analgesia. This elevation of pain 
      threshold (by 60-90%) could be observed already 2 min after i.c.v. injection and 
      lasted 15-30 min. Surprisingly, the analgesic action of i.c.v. treatment was not 
      attenuated if naloxone was administered i.c.v. instead of saline. In fact if 
      applying it in higher doses, the opiate antagonist potentiated the 
      antinociceptive action. However, giving naloxone subcutaneously (s.c.) before 
      i.c.v. saline treatment, the resulting analgesia was significantly reduced. It is 
      tentatively put forward that i.c.v. treatment is stressful and in itself may 
      induce mobilization of endogenous opioids and the latters elevate the pain 
      threshold via peripheral opiate mechanisms.
FAU - Miglecz, E
AU  - Miglecz E
FAU - Szekely, J I
AU  - Szekely JI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Res Commun
JT  - Pharmacological research communications
JID - 0236354
RN  - 0 (Receptors, Opioid)
RN  - 36B82AMQ7N (Naloxone)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Animals
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Naloxone/administration & dosage/pharmacology
MH  - Pain/*physiopathology
MH  - Reaction Time/drug effects
MH  - Receptors, Opioid/*drug effects
MH  - Sensory Thresholds/*drug effects
MH  - Sodium Chloride/administration & dosage/*pharmacology
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 10.1016/0031-6989(85)90063-3 [doi]
PST - ppublish
SO  - Pharmacol Res Commun. 1985 Feb;17(2):177-87. doi: 10.1016/0031-6989(85)90063-3.