PMID- 29863626
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20190320
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 64
IP  - 5
DP  - 2018 Sep/Oct
TI  - Speed Reduction Does Not Restore High Molecular Weight von Willebrand Multimers 
      During HeartMate II Support: An In Vivo Study.
PG  - e123-e125
LID - 10.1097/MAT.0000000000000831 [doi]
AB  - Acquired von Willebrand Syndrome (AVWS) in patients undergoing continuous-flow 
      left ventricular assist device support is due to the loss of von Willebrand 
      factor (vWF) high molecular weight multimers (HMWMs) by shear-mediated 
      mechanisms. We investigated whether reducing speed in vivo would mitigate the 
      shear effect. In outpatients (n = 6) with a HeartMate II, pump speed was 
      decreased to 8,000 rpm for 6 hours. At baseline (9,140 +/- 189 rpm), patients had 
      an AVWS as evidenced by low vWF activity:antigen ratios (0.58 +/- 0.13, normal 
      >0.7) and reduced HMWMs. After 6 hours, there was no significant change in either 
      the vWF activity:antigen ratio or the HMWMs. Decreasing pump speed does not 
      ameliorate AVWS.
FAU - Saeed, Omar
AU  - Saeed O
AD  - From the Division of Cardiology, Department of Medicine, Montefiore Medical 
      Center, Albert Einstein College of Medicine, Bronx, New York.
FAU - Rangasamy, Sabarivinoth
AU  - Rangasamy S
AD  - From the Division of Cardiology, Department of Medicine, Montefiore Medical 
      Center, Albert Einstein College of Medicine, Bronx, New York.
FAU - Reyes Gil, Morayma
AU  - Reyes Gil M
AD  - Department of Pathology, Montefiore Medical Center, Albert Einstein College of 
      Medicine, Bronx, New York.
FAU - Goldstein, Daniel J
AU  - Goldstein DJ
AD  - Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, 
      Albert Einstein College of Medicine, Bronx, New York.
FAU - Billett, Henny H
AU  - Billett HH
AD  - Division of Hematology, Department of Medicine, Montefiore Medical Center, Albert 
      Einstein College of Medicine, Bronx, New York.
FAU - Jorde, Ulrich P
AU  - Jorde UP
AD  - From the Division of Cardiology, Department of Medicine, Montefiore Medical 
      Center, Albert Einstein College of Medicine, Bronx, New York.
FAU - Patel, Snehal R
AU  - Patel SR
AD  - From the Division of Cardiology, Department of Medicine, Montefiore Medical 
      Center, Albert Einstein College of Medicine, Bronx, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (von Willebrand Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart-Assist Devices/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - von Willebrand Diseases/*etiology
MH  - von Willebrand Factor/*chemistry
EDAT- 2018/06/05 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/06/05 06:00
PHST- 2018/06/05 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/06/05 06:00 [entrez]
AID - 10.1097/MAT.0000000000000831 [doi]
PST - ppublish
SO  - ASAIO J. 2018 Sep/Oct;64(5):e123-e125. doi: 10.1097/MAT.0000000000000831.