PMID- 29865095
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20211204
IS  - 1878-7401 (Electronic)
IS  - 0928-7329 (Linking)
VI  - 26
IP  - 3
DP  - 2018
TI  - Association of sLR11 gene polymorphism with T2DM and carotid atherosclerosis.
PG  - 391-400
LID - 10.3233/THC-171040 [doi]
AB  - OBJECTIVE: To investigate the association of single nucleotide polymorphisms 
      (SNPs) of soluble low-density lipoprotein receptor 11 (sLR11) genes with type-2 
      diabetes mellitus (T2DM) and carotid atherosclerosis (CAS) in Korean and Han 
      nationalities in the Yanbian area. METHODS: 530 T2DM patients were divided into 
      two groups according to the intima-media thickness (IMT) of the carotid artery: 
      CAS group (n= 256, T2DM patients with carotid artery IMT ⩾ 1.0 mm and plaque) and 
      non-CAS group (NCAS group, n= 274, T2DM patients with carotid IMT < 1.0 mm). IMT 
      and plaque were measured by color Doppler ultrasound. SNP typing and sequencing 
      were performed by PCR-LDR. RESULTS: 1. Allele frequency and genotype frequency 
      distribution results: Differences in genotype and allele frequency distribution 
      between the CAS and NGT groups, the NCAS and NGT groups, and the CAS and NCAS 
      groups were not statistically significant (P> 0.05). The dominant and recessive 
      modes were analyzed, but the difference in genotype frequency among these three 
      groups was not statistically significant (P> 0.05). Differences in genotype 
      frequency distribution between Korean and Han populations in all three groups 
      were not statistically significant (P> 0.05). 2. Correlation analysis with 
      clinical indicators: LDL-C levels in TT and AT patients in the CAS group were 
      significantly higher than those in AA patients (P> 0.05), representing the 
      dominant mode of inheritance.. CONCLUSION: This study is the first to determine 
      that the sLR11 gene rs3824968 polymorphic of factor T may increase the risk of 
      CAS in T2DM patients by regulating the concentration of LDL-C, showing the 
      dominant mode of inheritance.
FAU - Du, Fei
AU  - Du F
AD  - Department of Cell Biology and Medical Genetics, Yanbian University Medical 
      College, Yanji, Jilin, China.
FAU - Li, Dan
AU  - Li D
AD  - Department of Endocrinology, Affiliated Hospital of Yanbian University, Yanji, 
      Jilin, China.
FAU - Piao, Lian-Shan
AU  - Piao LS
AD  - Department of Endocrinology, Affiliated Hospital of Yanbian University, Yanji, 
      Jilin, China.
FAU - Yang, Kang-Juan
AU  - Yang KJ
AD  - Department of Cell Biology and Medical Genetics, Yanbian University Medical 
      College, Yanji, Jilin, China.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Technol Health Care
JT  - Technology and health care : official journal of the European Society for 
      Engineering and Medicine
JID - 9314590
RN  - 0 (Low Density Lipoprotein Receptor-Related Protein-1)
SB  - IM
MH  - Carotid Artery Diseases/*complications/*genetics
MH  - Carotid Intima-Media Thickness
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Electrophoresis, Agar Gel
MH  - Ethnicity
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Low Density Lipoprotein Receptor-Related Protein-1/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Ultrasonography, Doppler, Color
OTO - NOTNLM
OT  - carotid intima media thickness
OT  - gene polymorphism
OT  - sLR11
OT  - type 2 diabetes mellitus
EDAT- 2018/06/06 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - THC171040 [pii]
AID - 10.3233/THC-171040 [doi]
PST - ppublish
SO  - Technol Health Care. 2018;26(3):391-400. doi: 10.3233/THC-171040.