PMID- 29865281
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20200928
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 6
DP  - 2018 Jun 3
TI  - Combining Short-Term Interval Training with Caloric Restriction Improves ss-Cell 
      Function in Obese Adults.
LID - 10.3390/nu10060717 [doi]
LID - 717
AB  - Although low-calorie diets (LCD) improve glucose regulation, it is unclear if 
      interval exercise (INT) is additive. We examined the impact of an LCD versus LCD 
      + INT training on ss-cell function in relation to glucose tolerance in obese 
      adults. Twenty-six adults (Age: 46 +/- 12 year; BMI 38 +/- 6 kg/m(2)) were randomized 
      to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day 
      alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test 
      (OGTT) was performed. Insulin secretion rates (ISR) were determined by 
      deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: 
      ISR/glucose total area under the curve (tAUC)]) and ss-cell function (Disposition 
      Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic 
      (HOMA-IR) and adipose (Adipose-IR(fasting)) insulin resistance (IR). LCD + INT, 
      but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 
      0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR 
      by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved 
      skeletal muscle DI was associated with lower glucose tAUC (r = -0.57, p < 0.01). 
      Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and 
      these findings relate to ss-cell function. These data support LCD + INT for 
      preserving pancreatic function for type 2 diabetes prevention.
FAU - Francois, Monique E
AU  - Francois ME
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, 
      USA. mf4rq@virginia.edu.
FAU - Gilbertson, Nicole M
AU  - Gilbertson NM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, 
      USA. nmg4xk@virginia.edu.
FAU - Eichner, Natalie Z M
AU  - Eichner NZM
AUID- ORCID: 0000-0003-3515-6649
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, 
      USA. nze8bz@virginia.edu.
FAU - Heiston, Emily M
AU  - Heiston EM
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, 
      USA. emh5bh@virginia.edu.
FAU - Fabris, Chiara
AU  - Fabris C
AD  - Center for Diabetes Technology, School of Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. cf9qe@virginia.edu.
FAU - Breton, Marc
AU  - Breton M
AD  - Center for Diabetes Technology, School of Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. mb6nt@virginia.edu.
FAU - Mehaffey, J Hunter
AU  - Mehaffey JH
AD  - Department of Surgery, School of Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. jhm9t@hscmail.mcc.virginia.edu.
FAU - Hassinger, Taryn
AU  - Hassinger T
AUID- ORCID: 0000-0003-3015-4126
AD  - Department of Surgery, School of Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. teh3rz@virginia.edu.
FAU - Hallowell, Peter T
AU  - Hallowell PT
AD  - Department of Surgery, School of Medicine, University of Virginia, 
      Charlottesville, VA 22903, USA. PTH2F@hscmail.mcc.virginia.edu.
FAU - Malin, Steven K
AU  - Malin SK
AD  - Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, 
      USA. skm6n@virginia.edu.
AD  - Division of Endocrinology and Metabolism, University of Virginia, 
      Charlottesville, VA 22903, USA. skm6n@virginia.edu.
AD  - Robert M. Berne Cardiovascular Research Center, University of Virginia, 
      Charlottesville, VA, 22903, USA. skm6n@virginia.edu.
LA  - eng
GR  - DP3 DK106826/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180603
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adipose Tissue/metabolism/physiopathology
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - *Caloric Restriction
MH  - Diabetes Mellitus/blood/diagnosis/physiopathology/*prevention & control
MH  - Female
MH  - *High-Intensity Interval Training
MH  - Humans
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/*metabolism
MH  - Liver/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/metabolism/physiopathology
MH  - Obesity/blood/diagnosis/physiopathology/*therapy
MH  - Time Factors
MH  - Treatment Outcome
MH  - Virginia
MH  - Weight Loss
PMC - PMC6024769
OTO - NOTNLM
OT  - caloric restriction
OT  - diabetes
OT  - exercise
OT  - glucose control
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2018/06/06 06:00
MHDA- 2018/10/30 06:00
PMCR- 2018/06/01
CRDT- 2018/06/06 06:00
PHST- 2018/04/28 00:00 [received]
PHST- 2018/05/24 00:00 [revised]
PHST- 2018/05/30 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - nu10060717 [pii]
AID - nutrients-10-00717 [pii]
AID - 10.3390/nu10060717 [doi]
PST - epublish
SO  - Nutrients. 2018 Jun 3;10(6):717. doi: 10.3390/nu10060717.