PMID- 29865867
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181114
IS  - 2063-5303 (Electronic)
IS  - 2062-5871 (Print)
IS  - 2062-5871 (Linking)
VI  - 7
IP  - 2
DP  - 2018 Jun 1
TI  - EEG correlates associated with the severity of gambling disorder and serum BDNF 
      levels in patients with gambling disorder.
PG  - 331-338
LID - 10.1556/2006.7.2018.43 [doi]
AB  - Background and aims This study aimed to evaluate the association between the 
      severity of pathological gambling, serum brain-derived neurotrophic factor (BDNF) 
      level, and the characteristics of quantitative electroencephalography (EEG) in 
      patients with gambling disorder. Methods A total of 55 male patients aged 18-65 
      with gambling disorder participated. The severity of pathological gambling was 
      assessed with the nine-item Problem Gambling Severity Index from the Canadian 
      Problem Gambling Index (CPGI-PGSI). The Beck Depression Inventory and Lubben 
      Social Network Scale were also assessed. Serum BDNF levels were assessed from 
      blood samples. The resting-state EEG was recorded while the eyes were closed, and 
      the absolute power of five frequency bands was analyzed: delta (1-4 Hz), theta 
      (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), and gamma (30-50 Hz). Results Serum 
      BDNF level was positively correlated with theta power in the right parietal 
      region (P4, r = .403, p = .011), beta power in the right parietal region (P4, 
      r = .456, p = .010), and beta power in the right temporal region (T8, r = .421, 
      p = .008). Gambling severity (CPGI-PGSI) was positively correlated with absolute 
      beta power in the left frontal region (F7, r = .284, p = .043) and central region 
      [(C3, r = .292, p = .038), (C4, r = .304, p = .030)]. Conclusions These findings 
      support the hypothesis that right-dominant lateralized correlations between BDNF 
      and beta and theta power reflect right-dominant brain activation in addiction. 
      The positive correlations between beta power and the severity of gambling 
      disorder may be associated with hyperexcitability and increased cravings. These 
      findings contribute to a better understanding of brain-based electrophysiological 
      changes and BDNF levels in patients with pathological gambling.
FAU - Kim, Kyoung Min
AU  - Kim KM
AD  - 1 Department of Psychiatry, Dankook University Hospital , Cheonan, Republic of 
      Korea.
FAU - Choi, Sam-Wook
AU  - Choi SW
AD  - 2 Department of Psychiatry, Korea Institute on Behavioral Addictions, True Mind 
      Mental Health Clinic , Seoul, Republic of Korea.
FAU - Lee, Jaewon
AU  - Lee J
AD  - 3 Department of Psychiatry, Korea Institute on Neuromodulation, Easybrain Center 
      , Seoul, Republic of Korea.
FAU - Kim, Jun Won
AU  - Kim JW
AD  - 4 Department of Psychiatry, Catholic University of Daegu School of Medicine , 
      Daegu, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180605
PL  - Hungary
TA  - J Behav Addict
JT  - Journal of behavioral addictions
JID - 101602037
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Electroencephalography
MH  - Gambling/*diagnosis/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Rest
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC6174577
OTO - NOTNLM
OT  - BDNF
OT  - gambling disorder
OT  - quantitative electroencephalography
OT  - resting state
EDAT- 2018/06/06 06:00
MHDA- 2018/10/05 06:00
PMCR- 2018/06/01
CRDT- 2018/06/06 06:00
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/10/05 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 10.1556/2006.7.2018.43 [doi]
PST - ppublish
SO  - J Behav Addict. 2018 Jun 1;7(2):331-338. doi: 10.1556/2006.7.2018.43. Epub 2018 
      Jun 5.