PMID- 29866394
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20221207
IS  - 0219-3108 (Electronic)
IS  - 1015-9584 (Linking)
VI  - 42
IP  - 1
DP  - 2019 Jan
TI  - From diabetes remedy to diabetes remission; could single-anastomosis gastric 
      bypass be a safe bridge to reach target in non-obese patients?
PG  - 307-313
LID - S1015-9584(18)30049-6 [pii]
LID - 10.1016/j.asjsur.2018.04.002 [doi]
AB  - BACKGROUND/AIMS: Type 2 diabetes mellitus (T2DM) is considered a chronic 
      progressive incurable metabolic disease. Single-anastomosis gastric bypass (SAGB) 
      has proved to be effective in obese patients, yet its impact on non-obese 
      diabetics is not extensively studied. The aim is to determine the anthropometric 
      and glycemic outcomes of SAGB as a proposed line of treatment for T2DM patients 
      with body mass index (BMI) 25-30 kg/m(2). METHODS: From November 2013 to March 
      2016, a prospective study has been conducted at Ain-Shams University Hospitals on 
      17 consecutive patients who have undergone SAGB. The demographic and 
      anthropometric data, as well as the relevant laboratory results, were reported. 
      Complete T2DM remission is considered if glycosylated hemoglobin (HbA1c) <6 % for 
      at least 1 year without medication, whereas partial remission is considered if 
      HbA1c<6.5%. RESULTS: The mean age was 42.6 +/-13.8 years, mean BMI was 26.7 +/- 2.3 
      kg/m(2) and mean duration of DM was 6.3 +/- 2.7 years. The mean baseline values of 
      HbA1c, FPG (fasting plasma glucose), and 2-hours postprandial glucose (2-H PPG) 
      were 9.9%, 176.3 mg/dl, and 310.3 mg/dl respectively. These values significantly 
      dropped at the 18(th) month to reach 5.8%, 93.4 mg/dl, and 156.2 mg/dl, with 
      13/17 patients became off-treatment (complete remission rate 76.4%). CONCLUSION: 
      T2DM patients with BMI 25-30 kg/m(2) are considered the most controversial group. 
      SAGB is an efficient metabolic procedure and could be integrated into the 
      treatment algorithm of T2DM. Such line of treatment opens new horizons to change 
      the concept of treatment from diabetes remedy to diabetes remission.
CI  - Copyright (c) 2018. Published by Elsevier Taiwan LLC.
FAU - Osman Abouzeid, Tarek Abouzeid
AU  - Osman Abouzeid TA
AD  - Department of General Surgery, College of Medicine, Ain-Shams University, Cairo, 
      Egypt. Electronic address: tarekabouzeid@ymail.com.
FAU - Ain Shoka, Ahmed Adel
AU  - Ain Shoka AA
AD  - Department of General Surgery, College of Medicine, Ain-Shams University, Cairo, 
      Egypt.
FAU - Abd Elsamee Atia, Karim Sabry
AU  - Abd Elsamee Atia KS
AD  - Department of General Surgery, College of Medicine, Ain-Shams University, Cairo, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20180602
PL  - Netherlands
TA  - Asian J Surg
JT  - Asian journal of surgery
JID - 8900600
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/metabolism/physiopathology/*surgery
MH  - Fasting/blood
MH  - Female
MH  - Gastric Bypass/*methods
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period
MH  - Prospective Studies
MH  - Remission Induction
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Bariatric/ metabolic surgery
OT  - Mini-gastric bypass
OT  - Single-anastomosis gastric bypass
OT  - Type II diabetes mellitus
OT  - Type II diabetes remission
EDAT- 2018/06/06 06:00
MHDA- 2019/04/09 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/01/28 00:00 [received]
PHST- 2018/03/08 00:00 [revised]
PHST- 2018/04/09 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - S1015-9584(18)30049-6 [pii]
AID - 10.1016/j.asjsur.2018.04.002 [doi]
PST - ppublish
SO  - Asian J Surg. 2019 Jan;42(1):307-313. doi: 10.1016/j.asjsur.2018.04.002. Epub 
      2018 Jun 2.