PMID- 29867348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 11
DP  - 2018
TI  - Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders.
PG  - 156
LID - 10.3389/fnmol.2018.00156 [doi]
LID - 156
AB  - Neurotrophins have been implicated in the pathophysiology of many 
      neuropsychiatric diseases. Brain-derived neurotrophic factor (BDNF) is the most 
      abundant and widely distributed neurotrophin in the brain. Its Val66Met 
      polymorphism (refSNP Cluster Report: rs6265) is a common and functional 
      single-nucleotide polymorphism (SNP) affecting the activity-dependent release of 
      BDNF. BDNF Val66Met transgenic mice have been generated, which may provide 
      further insight into the functional impact of this polymorphism in the brain. 
      Considering the important role of BDNF in brain function, more than 1,100 genetic 
      studies have investigated this polymorphism in the past 15 years. Although these 
      studies have reported some encouraging positive findings initially, most of the 
      findings cannot be replicated in following studies. These inconsistencies in BDNF 
      Val66Met genetic studies may be attributed to many factors such as age, sex, 
      environmental factors, ethnicity, genetic model used for analysis, and gene-gene 
      interaction, which are discussed in this review. We also discuss the results of 
      recent studies that have reported the novel functions of this polymorphism. 
      Because many BDNF polymorphisms and non-genetic factors have been implicated in 
      the complex traits of neuropsychiatric diseases, the conventional genetic 
      association-based method is limited to address these complex interactions. Future 
      studies should apply data mining and machine learning techniques to determine the 
      genetic role of BDNF in neuropsychiatric diseases.
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - School of Medicine, National Yang-Ming University, Taipei, Taiwan.
AD  - Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180515
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC5962780
OTO - NOTNLM
OT  - Val66Met polymorphism
OT  - age
OT  - brain-derived neurotrophic factor
OT  - environmental factors
OT  - ethnicity
OT  - genetic study
OT  - sex
OT  - transgenic mice
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:01
PMCR- 2018/01/01
CRDT- 2018/06/06 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/04/24 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2018.00156 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2018 May 15;11:156. doi: 10.3389/fnmol.2018.00156. 
      eCollection 2018.