PMID- 29867443
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 10
DP  - 2018
TI  - Low Plasma Leptin and High Soluble Leptin Receptor Levels Are Associated With 
      Mild Cognitive Impairment in Type 2 Diabetic Patients.
PG  - 132
LID - 10.3389/fnagi.2018.00132 [doi]
LID - 132
AB  - Background: Metabolic disturbances, such as hyperglycemia, hyperlipidemia, and 
      obesity, are thought to be risk factors for Alzheimer's disease. Objective: This 
      study aimed to investigate whether adipokine leptin and soluble leptin receptor 
      (sOBR) levels are correlated with mild cognitive impairment (MCI) and metabolic 
      status of the patients of type 2 diabetes mellitus (T2DM). Methods: Total of 169 
      T2DM patients were recruited and divided according to the Montreal Cognitive 
      Assessment (MoCA) score. Their cognition and metabolic parameters were 
      extensively assessed. Plasma leptin and sOBR levels were determined by RIA and 
      ELISA, respectively. Free leptin index (FLI) was calculated. Results: Of 124 
      enrolled T2DM patients, 61 were diagnosed with MCI (MoCA < 26). In MCI group and 
      female subgroup, leptin levels and FLI were significantly lower and sOBR 
      concentrations were higher when compared with their respective health cognition 
      controls (all p < 0.05). Leptin levels and FLI were positively associated with 
      the most cognitive domains and their Waist-to-Hip Ratio (WHR), a traditional 
      index of central obesity. Leptin, sOBR, and WHR were independent variables of MCI 
      in all individuals (all p < 0.05). For the females, MoCA was also positively 
      correlated with leptin (beta = 0.893, p < 0.001) and negatively correlated with WHR 
      (beta = -0.363, p = 0.014). Leptin was positively correlated only with WHR (beta = 
      0.441, p = 0.025). Conclusions: This study showed that a high level of leptin and 
      low level of sOBR are associated with the improved cognitive function in T2DM 
      patients and more significantly in female individuals, while WHR, as an indicator 
      of the visceral obesity, contributes to cognitive deficits. Trial registration: 
      Advanced Glycation End Products Induced Cognitive Impairment in Diabetes: BDNF 
      Signal Meditated Hippocampal Neurogenesis ChiCTR-OCC-15006060; 
      http://www.chictr.org.cn/showproj.aspx?proj=10536.
FAU - Yin, Han
AU  - Yin H
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Tian, Sai
AU  - Tian S
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Guo, Dan
AU  - Guo D
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Lin, Hongyan
AU  - Lin H
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Wang, Jiaqi
AU  - Wang J
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20180515
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC5962657
OTO - NOTNLM
OT  - leptin
OT  - mild cognitive impairment
OT  - type 2 diabetes
OT  - visceral obesity
OT  - waist-to-hip ration
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:01
PMCR- 2018/01/01
CRDT- 2018/06/06 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2018.00132 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2018 May 15;10:132. doi: 10.3389/fnagi.2018.00132. 
      eCollection 2018.