PMID- 29867505
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 9
DP  - 2018
TI  - Ontology-Based Meta-Analysis of Animal and Human Adverse Events Associated With 
      Licensed Brucellosis Vaccines.
PG  - 503
LID - 10.3389/fphar.2018.00503 [doi]
LID - 503
AB  - Brucella abortus strain 19 (S19), Brucella melitensis Rev 1 (Rev1), and B. 
      abortus strain RB51 (RB51) are the three licensed animal brucellosis vaccines, 
      and they have been most commonly and successfully used in prevent brucellosis in 
      animals. However, many adverse events (AEs) have been associated with these three 
      vaccines after their administering to animals or being accidentally exposed to 
      humans. In this study, 27 peer-reviewed publications containing animal and human 
      AE reports associated with these three brucellosis vaccines were manually 
      annotated from the PubMed database. Our meta-analysis identified 20 animal AEs 
      and 46 human AEs associated with the three vaccines. Based on the Ontology of 
      Adverse Events (OAE) hierarchical classification, these animal AEs were enriched 
      in the immune and reproductive systems that might eventually result in the 
      occurrence of abortion or infertility. The human AEs were concentrated in the 
      behavioral and neurological conditions, and these AEs showed flu-like symptoms 
      that are consistent with human brucellosis. Furthermore, an analysis of variance 
      (ANOVA) statistics analysis with linear model fits was used to determine the 
      major variables that might affect the occurrence of abortion AE in animals. The 
      ANOVA results indicated that three variables (P-value < 0.05) are significantly 
      associated with the occurrence of abortion AE: animal species, vaccination dose, 
      and vaccination route. The other two variables (i.e., vaccine type and animal age 
      at vaccination) did not significantly (P-value > 0.05) associated with the 
      occurrence of abortion AE. Overall, this study represents the first 
      ontology-based meta-analysis of adverse events associated with animal vaccines. 
      The results of such a study led to the better understanding of brucellosis 
      vaccine AEs, facilitating rational design of more secure and effective vaccines.
FAU - Xie, Jiangan
AU  - Xie J
AD  - School of Bioinformatics, Chongqing University of Posts and Telecommunications, 
      Chongqing, China.
AD  - Department of Computational Medicine and Bioinformatics, University of Michigan 
      Medical School, Ann Arbor, MI, United States.
FAU - Wang, Jessica
AU  - Wang J
AD  - Department of Computational Medicine and Bioinformatics, University of Michigan 
      Medical School, Ann Arbor, MI, United States.
FAU - Li, Zhangyong
AU  - Li Z
AD  - School of Bioinformatics, Chongqing University of Posts and Telecommunications, 
      Chongqing, China.
FAU - Wang, Wei
AU  - Wang W
AD  - School of Bioinformatics, Chongqing University of Posts and Telecommunications, 
      Chongqing, China.
FAU - Pang, Yu
AU  - Pang Y
AD  - School of Bioinformatics, Chongqing University of Posts and Telecommunications, 
      Chongqing, China.
FAU - He, Yongqun
AU  - He Y
AD  - Department of Computational Medicine and Bioinformatics, University of Michigan 
      Medical School, Ann Arbor, MI, United States.
LA  - eng
PT  - Journal Article
DEP - 20180515
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5962797
OTO - NOTNLM
OT  - ANOVA statistics analysis
OT  - Brucella
OT  - Ontology of Adverse Events
OT  - abortion AE
OT  - adverse event
OT  - brucellosis vaccine
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:01
PMCR- 2018/05/15
CRDT- 2018/06/06 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2018/04/26 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:01 [medline]
PHST- 2018/05/15 00:00 [pmc-release]
AID - 10.3389/fphar.2018.00503 [doi]
PST - epublish
SO  - Front Pharmacol. 2018 May 15;9:503. doi: 10.3389/fphar.2018.00503. eCollection 
      2018.