PMID- 29868224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 2054-4200 (Electronic)
IS  - 2054-4200 (Linking)
VI  - 2
DP  - 2017
TI  - Whole-genome association study of antibody response to Epstein-Barr virus in an 
      African population: a pilot.
PG  - e18
LID - 10.1017/gheg.2017.16 [doi]
LID - e18
AB  - Epstein Barr virus (EBV) infects 95% of the global population and is associated 
      with up to 2% of cancers globally. Immunoglobulin G (IgG) antibody levels to EBV 
      have been shown to be heritable and associated with developing malignancies. We, 
      therefore, performed a pilot genome-wide association analysis of anti-EBV IgG 
      traits in an African population, using a combined approach including array 
      genotyping, whole-genome sequencing and imputation to a panel with African 
      sequence data. In 1562 Ugandans, we identify a variant in human leukocyte antigen 
      (HLA)-DQA1, rs9272371 (p = 2.6 x 10(-17)) associated with anti-EBV nuclear 
      antigen-1 responses. Trans-ancestry meta-analysis and fine-mapping with 
      European-ancestry individuals suggest the presence of distinct HLA class II 
      variants driving associations in Uganda. In addition, we identify four putative, 
      novel, very rare African-specific loci with preliminary evidence for association 
      with anti-viral capsid antigen IgG responses which will require replication for 
      validation. These findings reinforce the need for the expansion of such studies 
      in African populations with relevant datasets to capture genetic diversity.
FAU - Sallah, N
AU  - Sallah N
AUID- ORCID: 0000-0002-2953-5311
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Virus Genomics, Wellcome Trust Sanger Institute, Hinxton, UK.
FAU - Carstensen, T
AU  - Carstensen T
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Wakeham, K
AU  - Wakeham K
AD  - MRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, 
      Uganda.
AD  - Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
FAU - Bagni, R
AU  - Bagni R
AD  - Protein Expression Lab, Cancer Research Technology Program, Leidos Biomedical 
      Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
FAU - Labo, N
AU  - Labo N
AD  - Viral Oncology Section, Aids and Cancer Program, Leidos Biomedical Research, 
      Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
FAU - Pollard, M O
AU  - Pollard MO
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Gurdasani, D
AU  - Gurdasani D
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Ekoru, K
AU  - Ekoru K
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Pomilla, C
AU  - Pomilla C
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Young, E H
AU  - Young EH
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Fatumo, S
AU  - Fatumo S
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
AD  - H3Africa Bioinformatics Network (H3ABioNet) Node, National Biotechnology 
      Development Agency (NABDA), Federal Ministry of Science and Technology (FMST), 
      Abuja, Nigeria.
FAU - Asiki, G
AU  - Asiki G
AD  - MRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, 
      Uganda.
FAU - Kamali, A
AU  - Kamali A
AD  - MRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, 
      Uganda.
FAU - Sandhu, M
AU  - Sandhu M
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
AD  - Department of Medicine, University of Cambridge, Cambridge, UK.
FAU - Kellam, P
AU  - Kellam P
AD  - Department of Virus Genomics, Wellcome Trust Sanger Institute, Hinxton, UK.
FAU - Whitby, D
AU  - Whitby D
AD  - Viral Oncology Section, Aids and Cancer Program, Leidos Biomedical Research, 
      Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
FAU - Barroso, I
AU  - Barroso I
AD  - Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
FAU - Newton, R
AU  - Newton R
AD  - MRC/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, 
      Uganda.
LA  - eng
GR  - G0901213/MRC_/Medical Research Council/United Kingdom
GR  - G0801566/MRC_/Medical Research Council/United Kingdom
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - MR/K013491/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20171127
PL  - England
TA  - Glob Health Epidemiol Genom
JT  - Global health, epidemiology and genomics
JID - 101703450
PMC - PMC5870407
OTO - NOTNLM
OT  - Africa
OT  - Epstein-Barr virus
OT  - genomics
OT  - immunity
OT  - infectious disease
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:01
PMCR- 2017/11/27
CRDT- 2018/06/06 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/10/19 00:00 [revised]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:01 [medline]
PHST- 2017/11/27 00:00 [pmc-release]
AID - 00016 [pii]
AID - 10.1017/gheg.2017.16 [doi]
PST - epublish
SO  - Glob Health Epidemiol Genom. 2017 Nov 27;2:e18. doi: 10.1017/gheg.2017.16. 
      eCollection 2017.