PMID- 29868638
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240318
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 6
IP  - 6
DP  - 2018 Jun
TI  - Endoscopic electrochemotherapy for esophageal cancer: a phase I clinical study.
PG  - E727-E734
LID - 10.1055/a-0590-4053 [doi]
AB  - BACKGROUND AND STUDY AIMS:  Esophageal cancer is on the rise in the western world 
      and the disease has a poor 5-year survival prognosis below 20 %. 
      Electrochemotherapy is a treatment where a chemotherapeutic drug is combined with 
      locally applied electrical pulses, in order to increase the drug's cytotoxicity 
      in malignant cells. This study presents the first results with 
      electrochemotherapy treatment in esophageal cancer. PATIENTS AND METHODS:  In 
      this first-in-human trial, six patients with advanced esophageal cancer were 
      treated with electrochemotherapy using intravenous bleomycin. All side effects 
      and adverse events (AEs) were registered and the patients were later evaluated 
      with gastroscopy and 18F-fluorodeoxyglucose positron emission tomography/magnetic 
      resonance imaging (18F-FDG PET/MRI). RESULTS:  Treatment were well tolerated, 
      main AEs being nausea, vomiting, oral thrush, pneumonia, retrosternal pain, 
      fever, and hoarseness. No serious complications were observed. Five patients had 
      a visual tumor response confirmed by gastroscopy. In two cases, these findings 
      were confirmed with 18F-FDG PET/MRI as it revealed a reduction of total tumor 
      mass. CONCLUSION:  Electrochemotherapy in patients with advanced esophageal 
      cancer was conducted without major safety concerns. This study paves the way for 
      larger studies, which may further elucidate response rates for and side effects 
      of this new treatment.
FAU - Egeland, Charlotte
AU  - Egeland C
AD  - Department of Surgical Gastroenterology, Rigshospitalet, University of 
      Copenhagen, Denmark.
FAU - Baeksgaard, Lene
AU  - Baeksgaard L
AD  - Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
FAU - Johannesen, Helle Hjorth
AU  - Johannesen HH
AD  - Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, 
      University of Copenhagen, Denmark.
FAU - Lofgren, Johan
AU  - Lofgren J
AD  - Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, 
      University of Copenhagen, Denmark.
FAU - Plaschke, Christina Caroline
AU  - Plaschke CC
AD  - Department of Otorhinolaryngology, Head and Neck Surgery & Audiology, 
      Rigshospitalet, University of Copenhagen, Denmark.
FAU - Svendsen, Lars Bo
AU  - Svendsen LB
AD  - Department of Surgical Gastroenterology, Rigshospitalet, University of 
      Copenhagen, Denmark.
FAU - Gehl, Julie
AU  - Gehl J
AD  - Center for Experimental Drug and Gene Electrotransfer (CEDGE), Department of 
      Clinical Oncology and Palliative Care, Herlev University Hospital, Copenhagen, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, Zealand 
      University Hospital, University of Copenhagen, Denmark.
FAU - Achiam, Michael Patrick
AU  - Achiam MP
AD  - Department of Surgical Gastroenterology, Rigshospitalet, University of 
      Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20180525
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC5979192
COIS- Competing interests None
EDAT- 2018/06/06 06:00
MHDA- 2018/06/06 06:01
PMCR- 2018/06/01
CRDT- 2018/06/06 06:00
PHST- 2018/01/29 00:00 [received]
PHST- 2018/02/08 00:00 [accepted]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/06/06 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 10.1055/a-0590-4053 [doi]
PST - ppublish
SO  - Endosc Int Open. 2018 Jun;6(6):E727-E734. doi: 10.1055/a-0590-4053. Epub 2018 May 
      25.