PMID- 29869414
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20191011
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 138
IP  - 5
DP  - 2018 Nov
TI  - HLA genetics in bipolar disorder.
PG  - 464-471
LID - 10.1111/acps.12912 [doi]
AB  - OBJECTIVE: Bipolar Disorder (BD) is characterized by deregulated adaptive immune 
      processes. Recent genome-wide association studies (GWAS) implicate the major 
      histocompatibility complex (MHC) region in BD. The present study investigates the 
      potential influence of variations in human leukocyte antigen (HLA) on BD risk 
      and/or clinical presentations. This may have relevance to the dysregulated 
      inflammatory processes commonly found in BD. METHOD: DNAs from 475 BD patients 
      and 195 healthy controls (HC) were genotyped for classical HLA class I and II 
      loci. RESULTS: We found that: (i) the HLA-A*02~B*44~DRB1*07 sub-haplotype is less 
      prevalent in BD, vs. HC (pc = 2.4 x 10(-2) ); (ii) the 57.1 and the 8.1-derived 
      ancestral haplotypes i.e. HLA-A*02~B*57~Cw*06~DRB1*07~DQB1*09 and 
      HLA-A*02~B*08~Cw*07 are associated with rapid cycling (pc = 1.9 x 10(-3) and 
      1.05 x 10(-2) , respectively); (iii) the 8.1AH-derived HLA class 
      II-DRB*03~HLA-DQB1*02 sub-haplotype is more frequent in BD patients with a 
      history of suicidal behaviors (pc = 2.1 x 10(-2) ); and (iv) disease onset by an 
      hypomanic episode or by psychotic symptoms are, respectively, more frequent in BD 
      patients bearing the 7.1 AH-derived A*03~B*07~DRB1*15 sub-haplotype 
      (pc = 8.5 x 10(-3) ) and the HLA-A*02~B*07~DRB1*15 sub-haplotype 
      (pc = 4.0 x 10(-2) ). CONCLUSION: Corroborating the established link between 
      these HLA haplotypes/sub haplotypes and common immune disorders, our findings 
      suggest possible HLA-mediated proinflammatory processes operating in BD.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Tamouza, R
AU  - Tamouza R
AUID- ORCID: 0000-0003-3992-9565
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
AD  - Cordons de Vie Association, Monaco and LabEx Transplantex, Strasbourg, France.
FAU - Oliveira, J
AU  - Oliveira J
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
FAU - Etain, B
AU  - Etain B
AUID- ORCID: 0000-0002-5377-1488
AD  - FondaMental Foundation, Creteil, France.
AD  - Department of Psychiatry & Addiction Medicine, INSERM UMR-S1144 - VariaPsy, 
      University Paris Diderot, AP-HP, Fernand Widal Hospital, Paris, France.
FAU - Bengoufa, D
AU  - Bengoufa D
AD  - INSERM, U1160, Saint Louis Hospital, Paris, France.
FAU - Hamdani, N
AU  - Hamdani N
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
FAU - Manier, C
AU  - Manier C
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - INSERM, U1160, Saint Louis Hospital, Paris, France.
FAU - Mariaselvam, C
AU  - Mariaselvam C
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - INSERM, U1160, Saint Louis Hospital, Paris, France.
FAU - Sundaresh, A
AU  - Sundaresh A
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - INSERM, U1160, Saint Louis Hospital, Paris, France.
FAU - Bellivier, F
AU  - Bellivier F
AUID- ORCID: 0000-0002-3660-6640
AD  - FondaMental Foundation, Creteil, France.
AD  - Department of Psychiatry & Addiction Medicine, INSERM UMR-S1144 - VariaPsy, 
      University Paris Diderot, AP-HP, Fernand Widal Hospital, Paris, France.
FAU - Henry, C
AU  - Henry C
AUID- ORCID: 0000-0002-1549-9604
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
FAU - Kahn, J-P
AU  - Kahn JP
AD  - Department of Psychiatry and Clinical Psychology, CHU of Nancy, Brabois 
      Hospitals, Vandoeuvre Les Nancy, France.
FAU - Krishnamoorthy, R
AU  - Krishnamoorthy R
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
FAU - Charron, D
AU  - Charron D
AD  - FondaMental Foundation, Creteil, France.
FAU - Leboyer, M
AU  - Leboyer M
AD  - INSERM, U955, Translational Psychiatry, Paris-East University, School of 
      Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, 
      Creteil, France.
AD  - FondaMental Foundation, Creteil, France.
LA  - eng
GR  - I-GIVE 13-SAMA-0004-01/Agence Nationale de la Recherche/International
GR  - U940/INSERM/International
GR  - U1160/INSERM/International
GR  - U955/INSERM/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180604
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - 0 (HLA-A Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bipolar Disorder/*genetics
MH  - Female
MH  - HLA-A Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Inflammation/*genetics
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - HLA haplotypes
OT  - bipolar disorder
OT  - inflammation
OT  - polarity at onset
OT  - rapid cycling
OT  - suicidal behavior
EDAT- 2018/06/06 06:00
MHDA- 2019/10/12 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - 10.1111/acps.12912 [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2018 Nov;138(5):464-471. doi: 10.1111/acps.12912. Epub 2018 
      Jun 4.