PMID- 29869708
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181114
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 275
IP  - 8
DP  - 2018 Aug
TI  - Oncological and functional outcomes of transoral laser surgery for laryngeal 
      carcinoma.
PG  - 2071-2077
LID - 10.1007/s00405-018-5027-z [doi]
AB  - INTRODUCTION: Transoral laser microsurgery (TLM) has become the standard approach 
      for treatment of early-stage laryngeal carcinoma in most institutions due to 
      their good oncological and functional results with few local complications. The 
      purpose of this study was to analyze the oncological and functional results of 
      TLM in the treatment of laryngeal tumors at our Hospital. MATERIALS AND METHODS: 
      Patients with laryngeal squamous cell carcinoma (LSCC) treated from 1998 to 2013 
      with TLM with curative intention, and with a minimum follow-up of 24 months, were 
      reviewed. RESULTS: 203 patients with LSCC were included. 195 patients were men 
      (96%) and 8 women (4%), with a mean age of 63 years. The series includes 134 
      (66%) T1, 40 (20%) T2, and 29 (14%) T3-classified tumors. 116 tumors (57%) were 
      in the glottis, 79 (39%) in the supraglottis and 8 (4%) in the anterior 
      commissure. 16 patients (8%) received adjuvant radiotherapy. Initial local 
      control was obtained in 75.5% of patients. The 5-year overall survival rate was 
      84% and the 5-year disease-specific survival was 90%. The presence of nodal 
      metastasis (p < 0.001) and the involvement of the surgical margins (p = 0.004) 
      were associated with a lower disease-specific survival in the multivariate 
      analysis. All but three patients with local control of the disease reassumed oral 
      diet, and none were tracheostomy-dependent. The 5-year laryngeal preservation 
      rate was 85%. CONCLUSIONS: TLM is a minimally invasive treatment for early and 
      moderately-advanced laryngeal carcinomas, with good oncologic and functional 
      outcomes, and few complications as well.
FAU - Pedregal-Mallo, Daniel
AU  - Pedregal-Mallo D
AUID- ORCID: 0000-0001-8899-7957
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain. pedregal.dm@gmail.com.
FAU - Sanchez Canteli, Mario
AU  - Sanchez Canteli M
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain.
FAU - Lopez, Fernando
AU  - Lopez F
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain.
FAU - Alvarez-Marcos, Cesar
AU  - Alvarez-Marcos C
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain.
FAU - Llorente, Jose Luis
AU  - Llorente JL
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain.
FAU - Rodrigo, Juan Pablo
AU  - Rodrigo JP
AD  - Department of Otolaryngology, Hospital Universitario Central de Asturias, 
      University of Oviedo, ISPA, IUOPA, CIBERONC, Av. Roma SN, 33011, Oviedo, 
      Asturias, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180605
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/diagnosis/physiopathology/*surgery
MH  - Deglutition/*physiology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/physiopathology/*surgery
MH  - Larynx/diagnostic imaging/physiopathology/*surgery
MH  - Laser Therapy/*methods
MH  - Male
MH  - Microsurgery/*methods
MH  - Middle Aged
MH  - Natural Orifice Endoscopic Surgery/*methods
MH  - Neoplasm Staging
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cancer
OT  - Larynx
OT  - Laser
OT  - Prognosis
OT  - Transoral
EDAT- 2018/06/06 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/03/10 00:00 [received]
PHST- 2018/05/29 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - 10.1007/s00405-018-5027-z [pii]
AID - 10.1007/s00405-018-5027-z [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2018 Aug;275(8):2071-2077. doi: 
      10.1007/s00405-018-5027-z. Epub 2018 Jun 5.