PMID- 29869957
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20240207
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 288
IP  - 2
DP  - 2018 Aug
TI  - Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in 
      the COPDGene Cohort.
PG  - 600-609
LID - 10.1148/radiol.2018172688 [doi]
AB  - Purpose To determine if interstitial features at chest CT enhance the effect of 
      emphysema on clinical disease severity in smokers without clinical pulmonary 
      fibrosis. Materials and Methods In this retrospective cohort study, an objective 
      CT analysis tool was used to measure interstitial features (reticular changes, 
      honeycombing, centrilobular nodules, linear scar, nodular changes, subpleural 
      lines, and ground-glass opacities) and emphysema in 8266 participants in a study 
      of chronic obstructive pulmonary disease (COPD) called COPDGene (recruited 
      between October 2006 and January 2011). Additive differences in patients with 
      emphysema with interstitial features and in those without interstitial features 
      were analyzed by using t tests, multivariable linear regression, and Kaplan-Meier 
      analysis. Multivariable linear and Cox regression were used to determine if 
      interstitial features modified the effect of continuously measured emphysema on 
      clinical measures of disease severity and mortality. Results Compared with 
      individuals with emphysema alone, those with emphysema and interstitial features 
      had a higher percentage predicted forced expiratory volume in 1 second (absolute 
      difference, 6.4%; P < .001), a lower percentage predicted diffusing capacity of 
      lung for carbon monoxide (DLCO) (absolute difference, 7.4%; P = .034), a 0.019 
      higher right ventricular-to-left ventricular (RVLV) volume ratio (P = .029), a 
      43.2-m shorter 6-minute walk distance (6MWD) (P < .001), a 5.9-point higher St 
      George's Respiratory Questionnaire (SGRQ) score (P < .001), and 82% higher 
      mortality (P < .001). In addition, interstitial features modified the effect of 
      emphysema on percentage predicted DLCO, RVLV volume ratio, 6WMD, SGRQ score, and 
      mortality (P for interaction < .05 for all). Conclusion In smokers, the combined 
      presence of interstitial features and emphysema was associated with worse 
      clinical disease severity and higher mortality than was emphysema alone. In 
      addition, interstitial features enhanced the deleterious effects of emphysema on 
      clinical disease severity and mortality.
CI  - (c) RSNA, 2018 Online supplemental material is available for this article.
FAU - Ash, Samuel Y
AU  - Ash SY
AUID- ORCID: 0000-0003-0224-6939
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Harmouche, Rola
AU  - Harmouche R
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Ross, James C
AU  - Ross JC
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Diaz, Alejandro A
AU  - Diaz AA
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Rahaghi, Farbod N
AU  - Rahaghi FN
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Vegas Sanchez-Ferrero, Gonzalo
AU  - Vegas Sanchez-Ferrero G
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Putman, Rachel K
AU  - Putman RK
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Hunninghake, Gary M
AU  - Hunninghake GM
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Onieva Onieva, Jorge
AU  - Onieva Onieva J
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Martinez, Fernando J
AU  - Martinez FJ
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Choi, Augustine M
AU  - Choi AM
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Bowler, Russell P
AU  - Bowler RP
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Lynch, David A
AU  - Lynch DA
AUID- ORCID: 0000-0002-6329-2325
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Hatabu, Hiroto
AU  - Hatabu H
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Bhatt, Surya P
AU  - Bhatt SP
AUID- ORCID: 0000-0002-8418-4497
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Dransfield, Mark T
AU  - Dransfield MT
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Wells, J Michael
AU  - Wells JM
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Rosas, Ivan O
AU  - Rosas IO
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - San Jose Estepar, Raul
AU  - San Jose Estepar R
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
FAU - Washko, George R
AU  - Washko GR
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
CN  - COPDGene Investigators
AD  - From the Division of Pulmonary and Critical Care Medicine, Department of Medicine 
      (S.Y.A., A.A.D., F.N.R., R.K.P., G.M.H., I.O.R., G.R.W.), Laboratory of 
      Mathematics in Imaging, Department of Radiology (R.H., J.C.R., G.V.S., J.O.O., 
      R.S.J.E.), and Department of Radiology (H.H.), Brigham and Women's Hospital, 75 
      Francis St, PBB CA-3, Boston, MA 02115; Department of Medicine, Weil Cornell 
      Medical College, New York, NY (F.J.M., A.M.C.); Departments of Medicine (R.P.B.) 
      and Radiology (D.A.L.), National Jewish Health, Denver, Colo; and Division of 
      Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University 
      of Alabama at Birmingham, Birmingham, Ala (S.P.B., M.T.D., J.M.W.).
LA  - eng
SI  - ClinicalTrials.gov/NCT00608764
GR  - R01 HL089897/HL/NHLBI NIH HHS/United States
GR  - T32 HL007633/HL/NHLBI NIH HHS/United States
GR  - R01 HL133137/HL/NHLBI NIH HHS/United States
GR  - R01 HL130974/HL/NHLBI NIH HHS/United States
GR  - R01 HL116931/HL/NHLBI NIH HHS/United States
GR  - R21 HL140422/HL/NHLBI NIH HHS/United States
GR  - R01 HL116473/HL/NHLBI NIH HHS/United States
GR  - R01 HL111024/HL/NHLBI NIH HHS/United States
GR  - R01 HL107246/HL/NHLBI NIH HHS/United States
GR  - P01 HL114501/HL/NHLBI NIH HHS/United States
GR  - R01 HL089856/HL/NHLBI NIH HHS/United States
GR  - K01 HL118714/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180605
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2018 Aug;288(2):610-611. PMID: 29869967
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/complications/*diagnostic 
      imaging/*physiopathology
MH  - Pulmonary Emphysema/complications/*diagnostic imaging/*physiopathology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC6069608
MID - NIHMS982439
EDAT- 2018/06/06 06:00
MHDA- 2018/08/23 06:00
PMCR- 2019/08/01
CRDT- 2018/06/06 06:00
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 10.1148/radiol.2018172688 [doi]
PST - ppublish
SO  - Radiology. 2018 Aug;288(2):600-609. doi: 10.1148/radiol.2018172688. Epub 2018 Jun 
      5.