PMID- 29870434
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20210109
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Print)
IS  - 1087-2418 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Aug
TI  - Assessment of human leukocyte antigen immunogenicity: current methods, challenges 
      and opportunities.
PG  - 477-485
LID - 10.1097/MOT.0000000000000544 [doi]
AB  - PURPOSE OF REVIEW: Donor-recipient human leukocyte antigen (HLA) matching 
      improves outcomes after solid-organ transplantation, but current assessment of 
      HLA incompatibility is inadequate as it does not consider the relative 
      immunogenicity of individual HLA mismatches. In this article, we review existing 
      strategies for assessing HLA immunogenicity and discuss current challenges and 
      future opportunities in this field. RECENT FINDINGS: Current HLA immunogenicity 
      algorithms focus primarily on the humoral component of the alloimmune response 
      and aim to determine a measure of 'dissimilarity' between donor and recipient 
      HLA. This can be achieved by deriving information from comparison of donor and 
      recipient HLA at the amino acid sequence, structural and/or the physicochemical 
      level, accounting for both B-cell and T-cell pathways of alloreactivity. 
      Substantial evidence now supports the superiority of this molecular definition of 
      HLA incompatibility, over conventional enumeration of HLA antigenic differences, 
      for assessing the risk of humoral alloimmunity and for predicting graft outcomes 
      after transplantation. SUMMARY: Significant progress has been made in developing 
      computational HLA immunogenicity algorithms that offer exciting opportunities for 
      a more rational approach to determining the degree of donor-recipient HLA 
      incompatibility and to defining HLA-related immunological risk. A number of 
      challenges now need to be overcome to enable their implementation into clinical 
      practice.
FAU - Copley, Hannah C
AU  - Copley HC
AD  - Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical 
      Research Centre, Cambridge University Hospitals NHS Foundation Trust, 
      Addenbrooke's Hospital.
FAU - Elango, Madhivanan
AU  - Elango M
AD  - Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical 
      Research Centre, Cambridge University Hospitals NHS Foundation Trust, 
      Addenbrooke's Hospital.
FAU - Kosmoliaptsis, Vasilis
AU  - Kosmoliaptsis V
AD  - Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical 
      Research Centre, Cambridge University Hospitals NHS Foundation Trust, 
      Addenbrooke's Hospital.
AD  - NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at 
      the University of Cambridge, Cambridge, UK.
LA  - eng
GR  - PDF-2016-09-065/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens/*immunology
MH  - Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Organ Transplantation/*methods
MH  - Tissue Donors
MH  - Transplantation Immunology
PMC - PMC6082597
EDAT- 2018/06/06 06:00
MHDA- 2019/05/21 06:00
PMCR- 2018/08/08
CRDT- 2018/06/06 06:00
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2018/08/08 00:00 [pmc-release]
AID - MOT230406 [pii]
AID - 10.1097/MOT.0000000000000544 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2018 Aug;23(4):477-485. doi: 
      10.1097/MOT.0000000000000544.