PMID- 29870695
OWN - NLM
STAT- MEDLINE
DCOM- 20190626
LR  - 20210309
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1696
DP  - 2018 Oct 1
TI  - Postconditioning with sevoflurane ameliorates spatial learning and memory deficit 
      via attenuating endoplasmic reticulum stress induced neuron apoptosis in a rat 
      model of hemorrhage shock and resuscitation.
PG  - 49-55
LID - S0006-8993(18)30323-8 [pii]
LID - 10.1016/j.brainres.2018.05.047 [doi]
AB  - Hemorrhage shock could initiate endoplasmic reticulum stress (ERS) and then 
      induce neuronal apoptosis. The aim of this study was to investigate whether 
      sevoflurane postconditioning could attenuate brain injury via suppressing 
      apoptosis induced by ERS. Seventy male rats were randomized into five groups: 
      sham, shock, low concentration (sevo1, 1.2%), middle concentration (sevo2, 2.4%) 
      and high concentration (sevo3, 3.6%) of sevoflurane postconditioning. Hemorrhage 
      shock was induced by removing 40% of the total blood volume during an interval of 
      30 min. 1 h after the completion of bleeding, the animals were reinfused with 
      shed blood during the ensuing 30 min. The spatial learning and memory ability of 
      rats were measured by Morris water maze (MWM) test three days after the 
      operation. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling 
      (TUNEL) positive cells in the hippocampus CA1 region were assessed after the MWM 
      test. The expression of C/EBP-homologousprotein (CHOP) and glucose-regulated 
      protein 78 (GRP78) in the hippocampus were measured at 24 h after reperfusion. We 
      found that sevoflurane postconditioning with the concentrations of 2.4% and 3.6% 
      significantly ameliorated the spatial learning and memory ability, decreased the 
      TUNEL-positive cells, and reduced the GRP78 and CHOP expression compared with the 
      shock group. These results suggested that sevoflurane postconditioning with the 
      concentrations of 2.4% and 3.6% could ameliorate spatial learning and memory 
      deficit after hemorrhage shock and resuscitation injury via suppressing apoptosis 
      induced by ERS.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hu, Xianwen
AU  - Hu X
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Wang, Jingxian
AU  - Wang J
AD  - Department of Anesthesiology, Lu'an Hospital Affiliated to Anhui Medical 
      University, Lu'an, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Zhang, Qiquan
AU  - Zhang Q
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Duan, Xiaowen
AU  - Duan X
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Zhang, Ye
AU  - Zhang Y
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, China. Electronic address: zhangye_hassan@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180602
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Ddit3 protein, rat)
RN  - 0 (GRP78 protein, rat)
RN  - 0 (Heat-Shock Proteins)
RN  - 147336-12-7 (Transcription Factor CHOP)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Brain Ischemia/metabolism
MH  - CA1 Region, Hippocampal/drug effects
MH  - Disease Models, Animal
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Heat-Shock Proteins/analysis
MH  - Hippocampus/metabolism
MH  - Intracranial Hemorrhages/*drug therapy
MH  - Ischemic Postconditioning/*methods
MH  - Learning/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Memory Disorders/physiopathology
MH  - Neurons/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/metabolism
MH  - Resuscitation
MH  - Sevoflurane/metabolism/*pharmacology
MH  - Spatial Learning/drug effects
MH  - Transcription Factor CHOP/analysis
OTO - NOTNLM
OT  - Endoplasmic reticulum stress
OT  - Hemorrhage shock and resuscitation
OT  - Sevoflurane postconditioning
OT  - Spatial learning and memory
EDAT- 2018/06/06 06:00
MHDA- 2019/06/27 06:00
CRDT- 2018/06/06 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/05/09 00:00 [revised]
PHST- 2018/05/30 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2019/06/27 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - S0006-8993(18)30323-8 [pii]
AID - 10.1016/j.brainres.2018.05.047 [doi]
PST - ppublish
SO  - Brain Res. 2018 Oct 1;1696:49-55. doi: 10.1016/j.brainres.2018.05.047. Epub 2018 
      Jun 2.