PMID- 29870991
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 98
IP  - 3
DP  - 2018
TI  - Factors Associated with Gastric Black Spot, White Flat Elevated Mucosa, and 
      Cobblestone-Like Mucosa: A Cross-Sectional Study.
PG  - 185-193
LID - 10.1159/000488796 [doi]
AB  - BACKGROUND/AIMS: Previous studies have reported a possible relevance between 
      proton pump inhibitor (PPI) use and 3 new gastric mucosal changes: black spots 
      (BSs), white flat elevated mucosa (WFEM), and cobblestone-like mucosa (CLM). The 
      aim of this study was to investigate the association between these mucosal 
      changes and multiple factors including PPI use. METHODS: All subjects who 
      underwent a routine esophagogastroduodenoscopy (EGD) were successively enrolled. 
      Endoscopists carried out the EGD after being blinded about -information on 
      patient PPI usage and determined the presence of these mucosal changes. The ratio 
      of each factor was -compared in cases with and without each gastric finding. 
      RESULTS: Out of 1,214 patients, BSs were recognized in 75 (6.2%) cases, WFEM in 
      59 (4.9%), and CLM in 41 (3.4%). In logistic regression analysis, PPI use was 
      significantly correlated with all of these findings (BSs: OR 2.94; 95% CI 
      1.66-5.21), (WFEM: OR 3.58; 95% CI 1.94-6.61), and (CLM: OR 4.57; 95% CI 
      2.34-9.96), and Helicobacter pylori eradication was related to BSs (OR 3.01; 95% 
      CI 1.73-5.24) and WFEM (OR 2.11; 95% CI 1.08-4.11). Decision-tree analyses showed 
      that H. pylori eradication was associated with all findings. CONCLUSIONS: All of 
      the considered findings were correlated with PPI and H. pylori eradication.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Hatano, Yu
AU  - Hatano Y
AD  - Shobara City Soryo Clinic, Shobara, Japan.
FAU - Haruma, Ken
AU  - Haruma K
AD  - Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical 
      School, General Medical Center, Okayama, Japan.
FAU - Kamada, Tomoari
AU  - Kamada T
AD  - Department of Health Care Medicine, Kawasaki Medical School, Kurashiki, Japan.
FAU - Shiotani, Akiko
AU  - Shiotani A
AD  - Division of Gastroenterology, Department of Internal Medicine, Kawasaki General 
      Medical Center, Kawasaki Medical School, Kurashiki, Japan.
FAU - Takahari, Kosuke
AU  - Takahari K
AD  - Department of Internal Medicine, Mitsugi General Hospital, Onomichi, Japan.
FAU - Matsumoto, Masatoshi
AU  - Matsumoto M
AD  - Department of Community-Based Medical System, Graduate School of Biomedical and 
      Health Sciences, Minami-ku, Japan.
FAU - Uchida, Osamu
AU  - Uchida O
AD  - Faculty of Informatics, Department of Informatics, Tokyo University of 
      Information Sciences, Wakaba-ku, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180605
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Endoscopy, Digestive System
MH  - Female
MH  - Gastric Mucosa/diagnostic imaging/drug effects/*pathology
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - Helicobacter pylori/drug effects/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - Black spot
OT  - Cobblestone-like mucosa
OT  - Helicobacter pylori eradication
OT  - Proton pump inhibitor
OT  - White flat elevated mucosa
EDAT- 2018/06/06 06:00
MHDA- 2019/01/29 06:00
CRDT- 2018/06/06 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/06/06 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/06/06 06:00 [entrez]
AID - 000488796 [pii]
AID - 10.1159/000488796 [doi]
PST - ppublish
SO  - Digestion. 2018;98(3):185-193. doi: 10.1159/000488796. Epub 2018 Jun 5.