PMID- 29870996 OWN - NLM STAT- MEDLINE DCOM- 20180731 LR - 20180731 IS - 1423-0097 (Electronic) IS - 1018-2438 (Linking) VI - 176 IP - 3-4 DP - 2018 TI - Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study. PG - 249-254 LID - 10.1159/000489337 [doi] AB - BACKGROUND: Wheat allergy is the third most common food allergy that develops during infancy in Japan. To identify factors associated with persistent wheat allergy, we assessed the rate of tolerance acquisition among Japanese children aged less than 6 years with an immediate-type wheat allergy using the oral food challenge (OFC) method. METHODS: This retrospective cohort study included 83 children (born in 2005-2006) who had a history of immediate-type allergic reaction to wheat and were followed until 6 years of age. The subjects were divided to form "tolerant" (n = 55; tolerance acquired by 6 years of age) and "allergic" (n = 28; tolerance not acquired by 6 years of age) groups based on their OFC results. RESULTS: The rates of tolerance acquisition to 200 g of udon noodles at 3, 5, and 6 years of age were 20.5% (17/83), 54.2% (45/83), and 66.3% (55/83), respectively. The total number of anaphylactic reactions experienced prior to 3 years of age in response to all foods (p < 0.01) and to wheat (p = 0.043) was significantly higher in the allergic than in the tolerant group. Wheat- and omega-5 gliadin-specific immunoglobulin E (IgE) levels were significantly higher in the allergic group than in the tolerant group (p < 0.01), and wheat-specific IgE levels were more likely to increase after infancy in the allergic group. CONCLUSIONS: A history of anaphylaxis to all foods including wheat and/or a high level of wheat- or omega-5 gliadin-specific IgE antibodies were identified as risk factors for persistent wheat allergy. CI - (c) 2018 S. Karger AG, Basel. FAU - Koike, Yumi AU - Koike Y AD - Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. AD - Department of General Pediatrics, Nagano Children's Hospital, Azumino, Japan. FAU - Yanagida, Noriyuki AU - Yanagida N AD - Department of Pediatrics, Sagamihara National Hospital, Sagamihara, Japan. FAU - Sato, Sakura AU - Sato S AD - Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. FAU - Asaumi, Tomoyuki AU - Asaumi T AD - Department of Pediatrics, Sagamihara National Hospital, Sagamihara, Japan. FAU - Ogura, Kiyotake AU - Ogura K AD - Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. FAU - Ohtani, Kiyotaka AU - Ohtani K AD - Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. AD - Department of Pediatrics, Sagamihara Kyodo Hospital, Sagamihara, Japan. FAU - Imai, Takanori AU - Imai T AD - Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan. FAU - Ebisawa, Motohiro AU - Ebisawa M AD - Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. LA - eng PT - Journal Article DEP - 20180605 PL - Switzerland TA - Int Arch Allergy Immunol JT - International archives of allergy and immunology JID - 9211652 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Immune Tolerance MH - Immunoglobulin E/blood MH - Infant MH - Male MH - Retrospective Studies MH - Triticum/immunology MH - Wheat Hypersensitivity/*etiology/immunology OTO - NOTNLM OT - Anaphylaxis OT - Gluten OT - Oral food challenge OT - Tolerance acquisition OT - Wheat allergy OT - Wheat-related specific IgE antibodies EDAT- 2018/06/06 06:00 MHDA- 2018/08/01 06:00 CRDT- 2018/06/06 06:00 PHST- 2017/05/17 00:00 [received] PHST- 2018/04/17 00:00 [accepted] PHST- 2018/06/06 06:00 [pubmed] PHST- 2018/08/01 06:00 [medline] PHST- 2018/06/06 06:00 [entrez] AID - 000489337 [pii] AID - 10.1159/000489337 [doi] PST - ppublish SO - Int Arch Allergy Immunol. 2018;176(3-4):249-254. doi: 10.1159/000489337. Epub 2018 Jun 5.