PMID- 29871220
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 31
IP  - 3
DP  - 2017 Feb 5
TI  - [The expression and clinical significance of RhoA, Ezrin and CD44 in laryngeal 
      squamous cell carcinoma].
PG  - 191-194
LID - 10.13201/j.issn.1001-1781.2017.03.006 [doi]
AB  - Objective:To investigate the expression of RhoA, Ezrin and CD44 proteins in 
      laryngeal squamous cell carcinoma (LSCC), and analyze their roles and mutual 
      relations in invasion and metastasis.Method:The expressions of RhoA, Ezrin and 
      CD44 in 68 specimens of LSCC and 35 specimens of normal laryngeal mucosa tissues 
      were detected by immunohistochemical SABC staining. The results were correlated 
      with clinicopathological parameters.Result:The positive expression rates of RhoA, 
      Ezrin and CD44 in LSCC were 80.9%,82,4% and 70.6%, and the positive expression 
      rates of RhoA, Ezrin and CD44 in normal laryngeal mucosa tissues were 28.5%, 
      25.7% and 20%, respectively. The expressions of RhoA, Ezrin and CD44 were 
      significantly correlated to depth of invasion (T), lymph node metastasis (N), 
      clinical TNM stage, tumor grade respectively (P< 0.05), but not to age, gender, 
      smoking, tumor location (P> 0.05). The expression of RhoA was positively 
      correlated to that of Ezrin in LSCC, and the expression of Ezrin was positively 
      correlated to that of CD44 in LSCC too (P< 0.05).Conclusion:Our findings 
      suggested that high expressions of RhoA, Ezrin and CD44 might play an important 
      role in the malignant progression of invasion and metastasis of LSCC, which 
      indicated that they might have played synergistic effects in the process.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Xie, Y X
AU  - Xie YX
AD  - Hebei North University, Zhangjiakou, 075000, China.
FAU - Shang, X L
AU  - Shang XL
AD  - Department of Otolaryngology, the First Affiliated Hospital of Hebei North 
      University.
FAU - Fan, J
AU  - Fan J
AD  - Hebei North University, Zhangjiakou, 075000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CD44 protein, human)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (ezrin)
RN  - 124671-05-2 (RHOA protein, human)
RN  - EC 3.6.5.2 (rhoA GTP-Binding Protein)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cytoskeletal Proteins/*metabolism
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Laryngeal Neoplasms/*metabolism
MH  - Prognosis
MH  - rhoA GTP-Binding Protein/*metabolism
OTO - NOTNLM
OT  - immunohistochemistry
OT  - laryngeal neoplasms
OT  - metastasis
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2017/02/05 00:00
MHDA- 2018/10/10 06:00
CRDT- 2018/06/06 06:00
PHST- 2016/10/07 00:00 [received]
PHST- 2018/06/06 06:00 [entrez]
PHST- 2017/02/05 00:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2017.03.006 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Feb 5;31(3):191-194. doi: 
      10.13201/j.issn.1001-1781.2017.03.006.