PMID- 29871779
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20221207
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 111
DP  - 2018 Nov
TI  - Association of ICAM-1 (K469E) and MCP-1-2518 A > G polymorphism with risk of 
      Japanese encephalitis in North Indian population.
PG  - 420-427
LID - S1043-4666(18)30219-9 [pii]
LID - 10.1016/j.cyto.2018.05.021 [doi]
AB  - BACKGROUND: Japanese encephalitis virus (JEV) is most important cause of viral 
      encephalitis worldwide. The pathogenesis of this is probably attributed to the 
      host genetic makeup. Intercellular adhesion molecule-1 (ICAM-1) and monocytes 
      chemoattractant protein-1 (MCP-1) play a vital role in host defense mechanism 
      against flavivirus causing encephalitis. We assessed the possible genetic 
      association between ICAM-1 (K469E) and MCP-1-2518 A > G polymorphisms and 
      Japanese Encephalitis in North Indian population. METHODS: We studied 
      ICAM-1(K469E) and MCP-1-2518 A > G polymorphisms with the help of polymerase 
      chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. 
      Expression of ICAM-1 and MCP-1 were determined at mRNA and protein levels in JE 
      patients and healthy controls by real-time polymerase chain reaction and 
      enzyme-linked immunosorbent assay (ELISA). RESULTS: Homozygous (E/E) genotype of 
      ICAM-1 was associated with clinical severity (p = 0.015) and outcome (p = 0.04) 
      of JE, whereas, heterozygous (A/G) genotype of MCP-1-2518 A > G was associated 
      with outcome in JE patients (p = 0.01). Among severe cases of JE, a higher level 
      of ICAM-1 was observed in patients with E allele (E/K + E/E) of ICAM-1 (K469E) 
      than non-E allele (K/K). The level of MCP-1 was found significantly increased in 
      JE patients with homozygous (G/G) genotype when compared to wild (A/A) genotype 
      of MCP-1-2518 A > G (p = 0.03). CONCLUSION: ICAM-1 (K469E) and MCP-1-2518 A > G 
      polymorphisms lead to increased level of ICAM-1 and MCP-1 in Japanese 
      Encephalitis which may be associated with severity as well as an adverse outcome 
      of the disease. ICAM-1 (K469E) polymorphism may affect host susceptibility to 
      Japanese encephalitis in North Indian population.
CI  - Copyright (c) 2018. Published by Elsevier Ltd.
FAU - Baluni, Manjari
AU  - Baluni M
AD  - Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar 
      Pradesh, India.
FAU - Fatima, Tanzeem
AU  - Fatima T
AD  - Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar 
      Pradesh, India.
FAU - Zia, Amreen
AU  - Zia A
AD  - Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar 
      Pradesh, India.
FAU - Himanshu Reddy, D
AU  - Himanshu Reddy D
AD  - King George Medical University, Lucknow 226003, Uttar Pradesh, India.
FAU - Dhole, Tapan N
AU  - Dhole TN
AD  - Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar 
      Pradesh, India. Electronic address: tndhole@sgpgi.ac.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180602
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Encephalitis Virus, Japanese/*pathogenicity
MH  - Encephalitis, Japanese/*genetics/virology
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - India
MH  - Intercellular Adhesion Molecule-1/*genetics
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Expression
OT  - ICAM-1
OT  - Japanese encephalitis
OT  - MCP-1
OT  - Polymorphisms
EDAT- 2018/06/07 06:00
MHDA- 2019/11/14 06:00
CRDT- 2018/06/07 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/04/14 00:00 [revised]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/06/07 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
PHST- 2018/06/07 06:00 [entrez]
AID - S1043-4666(18)30219-9 [pii]
AID - 10.1016/j.cyto.2018.05.021 [doi]
PST - ppublish
SO  - Cytokine. 2018 Nov;111:420-427. doi: 10.1016/j.cyto.2018.05.021. Epub 2018 Jun 2.