PMID- 29872771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 4
IP  - 5
DP  - 2018 May
TI  - Stevioside modulates oxidative damage in the liver and kidney of high fat/low 
      streptozocin diabetic rats.
PG  - e00640
LID - 10.1016/j.heliyon.2018.e00640 [doi]
LID - e00640
AB  - This study investigated the potential of stevioside to prevent oxidative DNA 
      damage in the liver and kidney of type 2 diabetes mellitus (T2DM) using high 
      fat-low streptozocin rat model. Rats were treated daily with 12.5, 25 and 50 
      mg/kg stevioside orally for 21 days. Levels of biomarkers of T2DM, lipid profile 
      and oxidative stress were assayed spectrophotometrically. The DNA ladder assay 
      method was used to assess DNA fragmentation in the liver and kidney while 
      computational analysis was used to predict the mechanisms of antidiabetic 
      properties of stevioside. Stevioside significantly (p < 0.05) decreased the 
      levels of plasma glucose, insulin, dipeptidyl peptidase IV and activities of 
      kidney angiotensin converting enzyme. Stevioside significantly reduced oxidative 
      stress by decreasing the levels of lipid peroxidation and nitric oxide in the 
      liver and kidney; thereby, reducing the extent of DNA fragmentation in the liver 
      and kidney of the diabetic rats. The in silico analysis showed that the ability 
      of stevioside to exert these effects is linked to its inhibition of 
      beta-adrenergic receptor kinase and G-protein-coupled receptor kinase. The 
      results of this study suggest that the prevention of DNA fragmentation may be an 
      additional benefit of the use of stevioside in the management of T2DM.
FAU - Rotimi, Solomon Oladapo
AU  - Rotimi SO
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
FAU - Rotimi, Oluwakemi Anuoluwapo
AU  - Rotimi OA
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
FAU - Adelani, Isaacson Bababode
AU  - Adelani IB
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
FAU - Onuzulu, Chinonye
AU  - Onuzulu C
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
FAU - Obi, Patience
AU  - Obi P
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
FAU - Okungbaye, Rotimi
AU  - Okungbaye R
AD  - Department of Biochemistry and Molecular Biology Research Laboratory, Covenant 
      University, Ota, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20180531
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC5986550
OTO - NOTNLM
OT  - Metabolism
OT  - Nutrition
EDAT- 2018/06/07 06:00
MHDA- 2018/06/07 06:01
PMCR- 2018/05/31
CRDT- 2018/06/07 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/05/08 00:00 [revised]
PHST- 2018/05/25 00:00 [accepted]
PHST- 2018/06/07 06:00 [entrez]
PHST- 2018/06/07 06:00 [pubmed]
PHST- 2018/06/07 06:01 [medline]
PHST- 2018/05/31 00:00 [pmc-release]
AID - S2405-8440(18)30182-8 [pii]
AID - e00640 [pii]
AID - 10.1016/j.heliyon.2018.e00640 [doi]
PST - epublish
SO  - Heliyon. 2018 May 31;4(5):e00640. doi: 10.1016/j.heliyon.2018.e00640. eCollection 
      2018 May.