PMID- 29873209
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 10
DP  - 2018 May
TI  - [Retrospective analysis of 760 laryngeal squamous cell carcinoma patients treated 
      with open laryngeal function-preserving operations].
PG  - 737-744
LID - 10.13201/j.issn.1001-1781.2018.10.004 [doi]
AB  - Objective:To explore the fundamental clinical characteristics and survival 
      prognostic factors of laryngeal squamous cell carcinoma (LSCC) patients treated 
      with open laryngeal function-preserving operations. Method: The collected 
      clinical data and the follow-up survival information from 760 patients with LSCC 
      undergoing open laryngeal function-preserving operations between January 2005 and 
      December 2010 in Eye & ENT Hospital of Fudan University were retrospectively 
      analyzed. Kaplan-Meier was applied to calculate survival rates. Log-rank test and 
      Cox regression model were performed to evaluate the survival prognostic factors 
      for univariate and multivariate analysis. Result: Among the enrolled 760 cases, 
      697 patients were glottic cancer, followed by 59 cases in supraglottis and 4 
      cases in subglottis. The number of laryngeal cancer patients staged in T1 to T4 
      was 222, 420, 112 and 6, respectively. 27 patients had positive cervical lymph 
      nodes. There were 220, 408, 111 and 21 patients with clinical stage Ⅰ to Ⅳ, 
      respectively. The 5-year overall survival (OS), disease free survival (DFS) and 
      disease specific survival (DSS) rates were 89.3%, 83.9% and 89.8%, respectively. 
      Multivariate Cox analysis indicated that clinical stage and second primary tumor 
      were independent influencing factors for the OS rate, while, age, primary site, 
      pathological differentiation, T stage, clinical stage and surgical margin were 
      independent risk factors for tumor recurrence and progression (P<0.05). 
      Conclusion: Open laryngeal function-preserving operation is a crucial therapeutic 
      strategy applicable to LSCC patients in early and selected advanced stage in 
      China. Early diagnosis and therapy, and sufficient safety surgical margin are 
      keys for improving the survival rate and reducing the risk of relapse for 
      laryngeal cancer patients.
FAU - Tao, L
AU  - Tao L
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Zhou, L
AU  - Zhou L
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Wu, H T
AU  - Wu HT
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Li, X M
AU  - Li XM
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Chen, X L
AU  - Chen XL
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Li, C
AU  - Li C
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Xie, M
AU  - Xie M
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Zhang, M
AU  - Zhang M
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Cheng, L
AU  - Cheng L
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
FAU - Tang, D
AU  - Tang D
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital of Fudan 
      University, Shanghai, 200031, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
SB  - IM
MH  - Carcinoma, Squamous Cell/*surgery
MH  - Humans
MH  - Laryngeal Neoplasms/*surgery
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
OTO - NOTNLM
OT  - laryngeal squamous cell carcinoma
OT  - open laryngeal function-preserving operation
OT  - risk factors
OT  - survival prognosis
EDAT- 2018/06/07 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/06/07 06:00
PHST- 2018/03/17 00:00 [received]
PHST- 2018/06/07 06:00 [entrez]
PHST- 2018/06/07 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2018.10.004 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 May;32(10):737-744. doi: 
      10.13201/j.issn.1001-1781.2018.10.004.