PMID- 29874672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 76
IP  - 3
DP  - 2017
TI  - The Effects of a BDNF Val66Met Polymorphism on Posttraumatic Stress Disorder: A 
      Meta-Analysis.
PG  - 136-142
LID - 10.1159/000489407 [doi]
AB  - OBJECTIVE: Given evidence that posttraumatic stress disorder (PTSD) is moderately 
      heritable, a number of studies utilizing candidate gene approaches have attempted 
      to examine the potential contributions of theoretically relevant genetic 
      variation. Some of these studies have found sup port for a brain-derived 
      neurotrophic factor (BDNF) variant, Val66Met, in the risk of developing PTSD, 
      while others have failed to find this link. METHODS: This study sought to 
      reconcile these conflicting findings using a meta-analysis framework. Analyses 
      were also used to determine whether there is significant heterogeneity in the 
      link between this variant and PTSD. We conducted a systematic review of the 
      literature on BDNF and PTSD from the PsycINFO and PubMed databases. A total of 11 
      studies were included in the analysis. RESULTS: Findings indicate a marginally 
      significant effect of the BDNF Val66Met variant on PTSD (p < 0.1). However, of 
      the 11 studies included, only 2 suggested an effect with a non-zero confidence 
      interval, one of which showed a z score of 3.31. We did not find any evidence for 
      heterogeneity. CONCLUSIONS: Findings from this meta-analytic investigation of the 
      published literature provide little support for the Val66Met variant of BDNF as a 
      predictor of PTSD. Future well-powered agnostic genome-wide association studies 
      with more refined phenotyping are needed to clarify genetic influences on PTSD.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Bountress, Kaitlin E
AU  - Bountress KE
AD  - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth 
      University, Richmond, Virginia, USA.
FAU - Bacanu, Silviu-Alin
AU  - Bacanu SA
AD  - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth 
      University, Richmond, Virginia, USA.
FAU - Tomko, Rachel L
AU  - Tomko RL
AD  - Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division, 
      Medical University of South Carolina, Charleston, South Carolina, USA.
FAU - Korte, Kristina J
AU  - Korte KJ
AD  - Department of Psychiatry, Division of Global Psychiatry, Massachusetts General 
      Hospital, Boston, Massachusetts, USA.
FAU - Hicks, Terrell
AU  - Hicks T
AD  - Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, 
      USA.
FAU - Sheerin, Christina
AU  - Sheerin C
AD  - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth 
      University, Richmond, Virginia, USA.
FAU - Lind, Mackenzie J
AU  - Lind MJ
AD  - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth 
      University, Richmond, Virginia, USA.
FAU - Marraccini, Marisa
AU  - Marraccini M
AD  - School of Education, University of North Carolina, Chapel Hill, North Carolina, 
      USA.
FAU - Nugent, Nicole
AU  - Nugent N
AD  - Departments of Pediatrics and Psychiatry and Human Behavior, Warren Alpert 
      Medical School of Brown University, Providence, Rhode Island, USA.
FAU - Amstadter, Ananda B
AU  - Amstadter AB
AD  - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth 
      University, Richmond, Virginia, USA.
LA  - eng
GR  - R01 MH105379/MH/NIMH NIH HHS/United States
GR  - R01 MH108641/MH/NIMH NIH HHS/United States
GR  - T32 MH020030/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20180606
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
PMC - PMC6057796
MID - NIHMS963600
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Meta-analysis
OT  - Posttraumatic stress disorder
COIS- Conflicts of Interest The authors declare no conflicts of interest.
EDAT- 2018/06/07 06:00
MHDA- 2018/06/07 06:01
PMCR- 2019/06/06
CRDT- 2018/06/07 06:00
PHST- 2018/02/22 00:00 [received]
PHST- 2018/04/19 00:00 [accepted]
PHST- 2018/06/07 06:00 [pubmed]
PHST- 2018/06/07 06:01 [medline]
PHST- 2018/06/07 06:00 [entrez]
PHST- 2019/06/06 00:00 [pmc-release]
AID - 000489407 [pii]
AID - 10.1159/000489407 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2017;76(3):136-142. doi: 10.1159/000489407. Epub 2018 Jun 6.