PMID- 29874709
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20240229
IS  - 2590-7379 (Electronic)
IS  - 0120-4157 (Linking)
VI  - 38 Suppl 1
DP  - 2018 May 1
TI  - Vitamin D and risk of preeclampsia: A systematic review and meta-analysis.
PG  - 43-53
LID - 10.7705/biomedica.v38i0.3683 [doi]
AB  - INTRODUCTION: Human vitamin D levels have been increasingly related to a wide 
      range of clinical outcomes. There is a large amount of reports on its 
      associations, especially with obstetric complications, including preeclampsia and 
      gestational diabetes. These results are scarcely consistent and there is still a 
      lack of quality intervention studies to confirm the role of vitamin D in those 
      outcomes. Objective: To review the available scientific evidence on the role of 
      maternal vitamin D in the development of preeclampsia. MATERIALS AND METHODS: The 
      methodology used followed the recommendations of the Cochrane guide for the 
      preparation of systematic reviews, and for metaanalysis, the Guide of the 
      Metaanalysis of Observational Studies in Epidemiology group (MOOSE). The search 
      included both observational studies and controlled clinical trials. RESULTS: Low 
      vitamin D levels, measured by the 25-hydroxyvitamin D test, are common in 
      pregnancy. The results of this systematic review and metaanalysis suggest an 
      inverse ratio between vitamin D levels and the development of preeclampsia. There 
      was heterogeneity among the studies with regard to the design, population, 
      geographic location, definitions of exposure, and the outcome. We excluded 
      randomized controlled trials from this meta-analysis. CONCLUSION: The inverse 
      association we found suggests that the higher the levels of vitamin D the lesser 
      the probability of developing preeclampsia, in spite of the heterogeneity of the 
      global measurement in this type of analysis.
FAU - Serrano-Diaz, Norma Cecilia
AU  - Serrano-Diaz NC
AD  - Grupo de Investigacion Biomedica Traslacional, Fundacion Cardiovascular de 
      Colombia, Bucaramanga, Colombia. biomedica@ins.gov.co.
FAU - Gamboa-Delgado, Edna Magaly
AU  - Gamboa-Delgado EM
FAU - Dominguez-Urrego, Clara Lucia
AU  - Dominguez-Urrego CL
FAU - Vesga-Varela, Andrea Liliana
AU  - Vesga-Varela AL
FAU - Serrano-Gomez, Sergio Eduardo
AU  - Serrano-Gomez SE
FAU - Quintero-Lesmes, Doris Cristina
AU  - Quintero-Lesmes DC
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20180501
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
RN  - 1406-16-2 (Vitamin D)
RN  - 0 (Vitamins)
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Pre-Eclampsia/blood/epidemiology/etiology
MH  - Risk Factors
MH  - *Vitamin D/blood
MH  - *Vitamin D Deficiency/complications
MH  - *Vitamins/blood
OTO - NOTNLM
OT  - calcifediol
OT  - calcitriol
OT  - Vitamin D
OT  - pre-eclampsia
OT  - cholecalciferol
OT  - pregnancy
OT  - review
OT  - metaanalysis
EDAT- 2018/06/07 06:00
MHDA- 2019/02/08 06:00
CRDT- 2018/06/07 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2018/06/07 06:00 [entrez]
PHST- 2018/06/07 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
AID - 10.7705/biomedica.v38i0.3683 [doi]
PST - epublish
SO  - Biomedica. 2018 May 1;38 Suppl 1:43-53. doi: 10.7705/biomedica.v38i0.3683.