PMID- 29874755
OWN - NLM
STAT- MEDLINE
DCOM- 20180824
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 193
DP  - 2018 Feb
TI  - Response mechanisms to joint exposure of triclosan and its chlorinated 
      derivatives on zebrafish (Danio rerio) behavior.
PG  - 820-832
LID - S0045-6535(17)31883-0 [pii]
LID - 10.1016/j.chemosphere.2017.11.106 [doi]
AB  - Triclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol 
      (2,4-DCP) frequently co-exist in real-world aquatic environments; the latter two 
      contaminants contributing to TCS photolytic products or chlorinated derivatives. 
      There is a paucity of information regarding their joint toxicity to aquatic 
      organisms leading us to study their effects on the swimming behavior of zebrafish 
      (Danio rerio). Herein, we reported that 0.28 mg/L TDT exposure (mixtures of TCS, 
      2,4,6-TCP and 2,4-DCP) enhanced 24-hpf embryonic spontaneous movement frequency, 
      96-hpf larval activity; however, the 0.56 and 1.12 mg/L TDT treatments decreased 
      all of these behavioral endpoints. All adult behavioral tests demonstrated that 
      chronic TDT exposure (0.14 mg/L) led to hyperactivity and restlessness in adult 
      zebrafish. A 0.14 mg/L TD DATE /@ "M/d/yyyy" 11/21/2017T treatment led to 
      anxiety-like behavior in a bottom dwelling test and excessive panic and low 
      hedging capacity in a conditioned place preference test. Social interaction test 
      demonstrated that zebrafish preferred quiet and isolated space in response to TDT 
      stress. Zebrafish memory was significantly decreased in a T-maze experiment. 
      Whole mount in situ hybridization of pax2a and bcl2l11 genes revealed that their 
      differential expression in the brain and skeleton were related to the 
      corresponding phenotypic behavioral abnormality. A series of biomarker and 
      estrogen receptor assays demonstrated that TDT acute exposure caused abnormal 
      energy metabolism and neurological diseases. AO staining revealed that TDT 
      exposure produced vascular ablation in the head, as well as the occurrence of 
      massive apoptosis in the brain. TEM observation showed pyknosis of nucleus 
      following TDT exposure. These results allow assessment of mechanisms for 
      zebrafish abnormal behavior in response to TDT exposure, and are useful for early 
      intervention and gene therapy of contaminant-induced diseases.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Liu, Jinfeng
AU  - Liu J
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China.
FAU - Sun, Limei
AU  - Sun L
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China.
FAU - Zhang, Hongqin
AU  - Zhang H
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China.
FAU - Shi, Mengru
AU  - Shi M
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China.
FAU - Dahlgren, Randy A
AU  - Dahlgren RA
AD  - Department of Land, Air and Water Resources, University of California, Davis, CA 
      95616, USA.
FAU - Wang, Xuedong
AU  - Wang X
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China. 
      Electronic address: zjuwxd@163.com.
FAU - Wang, Huili
AU  - Wang H
AD  - School of Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China. 
      Electronic address: whuili@163.com.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Water Pollutants, Chemical)
RN  - 4NM5039Y5X (Triclosan)
SB  - IM
MH  - Animals
MH  - Halogenation
MH  - Joints/*drug effects
MH  - Triclosan/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
MH  - Zebrafish
OTO - NOTNLM
OT  - Behavioral endpoint
OT  - Biomarker and estrogen receptor
OT  - Histopathological observation
OT  - Joint exposure to triclosan and its derivatives
OT  - Neurodevelopmental-related genes
EDAT- 2018/06/08 06:00
MHDA- 2018/08/25 06:00
CRDT- 2018/06/08 06:00
PHST- 2017/10/24 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/11/20 00:00 [accepted]
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2018/08/25 06:00 [medline]
AID - S0045-6535(17)31883-0 [pii]
AID - 10.1016/j.chemosphere.2017.11.106 [doi]
PST - ppublish
SO  - Chemosphere. 2018 Feb;193:820-832. doi: 10.1016/j.chemosphere.2017.11.106. Epub 
      2017 Nov 21.