PMID- 29874791
OWN - NLM
STAT- MEDLINE
DCOM- 20181015
LR  - 20181114
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Jun 5
TI  - Connexins and Pannexins in Vascular Function and Disease.
LID - 10.3390/ijms19061663 [doi]
LID - 1663
AB  - Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming 
      proteins that are critically involved in many aspects of vascular physiology and 
      pathology. The permeation of ions and small metabolites through Panx channels, Cx 
      hemichannels and gap junction channels confers a crucial role to these proteins 
      in intercellular communication and in maintaining tissue homeostasis. This review 
      provides an overview of current knowledge with respect to the pathophysiological 
      role of these channels in large arteries, the microcirculation, veins, the 
      lymphatic system and platelet function. The essential nature of these membrane 
      proteins in vascular homeostasis is further emphasized by the pathologies that 
      are linked to mutations and polymorphisms in Cx and Panx genes.
FAU - Molica, Filippo
AU  - Molica F
AUID- ORCID: 0000-0002-0405-5397
AD  - Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, 
      Switzerland. filippo.Molica@unige.ch.
FAU - Figueroa, Xavier F
AU  - Figueroa XF
AD  - Departamento de Fisiologia, Faculdad de Ciencias Biologicas, Pontifica 
      Universidad Catolica de Chile, Santiago 8330025, Chile. xfigueroa@bio.puc.cl.
FAU - Kwak, Brenda R
AU  - Kwak BR
AUID- ORCID: 0000-0003-0015-0044
AD  - Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, 
      Switzerland. brenda.kwakchanson@unige.ch.
FAU - Isakson, Brant E
AU  - Isakson BE
AD  - Robert M. Berne Cardiovascular Research Center, University of Virginia School of 
      Medicine, Charlottesville, VA 22908, USA. bei6n@virginia.edu.
AD  - Department of Molecular Physiology and Biophysics, University of Virginia School 
      of Medicine, Charlottesville, VA 22908, USA. bei6n@virginia.edu.
FAU - Gibbins, Jonathan M
AU  - Gibbins JM
AUID- ORCID: 0000-0002-0372-5352
AD  - Institute for Cardiovascular & Metabolic Research, School of Biological Sciences, 
      Harborne Building, University of Reading, Reading RG6 6AS, UK. 
      j.m.gibbins@reading.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180605
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Connexins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PANX1 protein, human)
SB  - IM
MH  - Cardiovascular Physiological Phenomena/*genetics
MH  - Connexins/*genetics/metabolism
MH  - Coronary Vessels/metabolism/*physiology
MH  - Gap Junctions/genetics
MH  - Homeostasis
MH  - Humans
MH  - Ion Channels/*genetics
MH  - Membrane Proteins/genetics
MH  - Nerve Tissue Proteins/genetics
PMC - PMC6032213
OTO - NOTNLM
OT  - connexin
OT  - pannexin
OT  - vascular disease
OT  - vascular physiology
COIS- The authors declare no conflict of interest.
EDAT- 2018/06/08 06:00
MHDA- 2018/10/16 06:00
PMCR- 2018/06/01
CRDT- 2018/06/08 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/05/28 00:00 [revised]
PHST- 2018/05/31 00:00 [accepted]
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2018/10/16 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - ijms19061663 [pii]
AID - ijms-19-01663 [pii]
AID - 10.3390/ijms19061663 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Jun 5;19(6):1663. doi: 10.3390/ijms19061663.