PMID- 29875362
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20191011
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jun 6
TI  - Lumbosacral spinal cord epidural stimulation improves voiding function after 
      human spinal cord injury.
PG  - 8688
LID - 10.1038/s41598-018-26602-2 [doi]
LID - 8688
AB  - Deficits in urologic function after spinal cord injury (SCI) manifest both as a 
      failure to store and empty, greatly impacting daily life. While current 
      management strategies are necessary for urological maintenance, they oftentimes 
      are associated with life-long side effects. Our objective was to investigate the 
      efficacy of spinal cord epidural stimulation (scES) as a promising therapy to 
      improve bladder control after SCI. A bladder mapping study was undertaken for 
      sixteen sessions over the course of four months in an individual with chronic, 
      motor complete SCI. Varying combinations of stimulating cathode electrodes were 
      initially tested during filling cystometry resulting in the identification of an 
      effective configuration for reflexive bladder emptying at the caudal end of the 
      electrode array. Subsequent systematic testing of different frequencies at a 
      fixed stimulus intensity and pulse width yielded lowest post-void residual 
      volumes at 30 Hz. These stimulation parameters were then tested in four 
      additional research participants and found to also improve reflexive voiding 
      efficiency. Taken together with SCI studies on step, stand, voluntary motor 
      control and cardiovascular regulation, these findings further corroborate that 
      scES has an all-encompassing potential to increase the central state of 
      excitability, allowing for the control of multiple body functions, including the 
      urological system.
FAU - Herrity, A N
AU  - Herrity AN
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
AD  - Department of Neurological Surgery, University of Louisville, Louisville, KY, 
      USA.
FAU - Williams, C S
AU  - Williams CS
AD  - Department of Urology, University of Louisville, Louisville, KY, USA.
FAU - Angeli, C A
AU  - Angeli CA
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
AD  - Frazier Rehab Institute, Louisville, KY, USA.
FAU - Harkema, S J
AU  - Harkema SJ
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
AD  - Department of Neurological Surgery, University of Louisville, Louisville, KY, 
      USA.
AD  - Frazier Rehab Institute, Louisville, KY, USA.
FAU - Hubscher, C H
AU  - Hubscher CH
AUID- ORCID: 0000-0002-6678-750X
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA. chhubs01@louisville.edu.
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville, 
      Louisville, KY, USA. chhubs01@louisville.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180606
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Humans
MH  - Lumbosacral Region/physiopathology
MH  - Male
MH  - Spinal Cord/*physiopathology
MH  - Spinal Cord Injuries/*physiopathology/*therapy
MH  - Spinal Cord Stimulation/*methods
MH  - Urinary Bladder/physiopathology
MH  - *Urination
PMC - PMC5989228
COIS- The authors declare no competing interests.
EDAT- 2018/06/08 06:00
MHDA- 2019/10/12 06:00
PMCR- 2018/06/06
CRDT- 2018/06/08 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/05/15 00:00 [accepted]
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PHST- 2018/06/06 00:00 [pmc-release]
AID - 10.1038/s41598-018-26602-2 [pii]
AID - 26602 [pii]
AID - 10.1038/s41598-018-26602-2 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jun 6;8(1):8688. doi: 10.1038/s41598-018-26602-2.