PMID- 29875666
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 9
DP  - 2018
TI  - Fast Green FCF Alleviates Pain Hypersensitivity and Down-Regulates the Levels of 
      Spinal P2X4 Expression and Pro-inflammatory Cytokines in a Rodent Inflammatory 
      Pain Model.
PG  - 534
LID - 10.3389/fphar.2018.00534 [doi]
LID - 534
AB  - Fast Green FCF (FGF), a biocompatible dye, recently drew attention as a potential 
      drug to treat amyloid-deposit diseases due to its effects against amyloid 
      fibrillogenesis in vitro and a high degree of safety. However, its role in 
      inflammatory pain is unknown. Our study aimed to investigate the effect of FGF in 
      the inflammatory pain model induced by complete Freund's adjuvant (CFA) and to 
      identify the associated mechanisms. We found that systemic administration of FGF 
      reversed mechanical and thermal pain hypersensitivity evoked by CFA in a 
      dose-dependent manner. FGF treatment decreased purinergic spinal P2X4 expression 
      in the spinal cord of CFA-inflamed mice. FGF also down-regulated spinal and 
      peripheral pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-1beta (IL-1beta), and interleukin-6 (IL-6)], but did not alter the spinal 
      level of nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF). 
      In conclusion, our results suggest the potential of FGF for controlling the 
      progress of inflammatory pain.
FAU - Xu, Fang
AU  - Xu F
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Lu, Fan
AU  - Lu F
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Liu, Rongjun
AU  - Liu R
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Zheng, Jinwei
AU  - Zheng J
AD  - Department of Anesthesiology, Ningbo No. 2 Hospital, Ningbo, China.
FAU - Zhang, Junfang
AU  - Zhang J
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Cui, Wei
AU  - Cui W
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Wang, Chuang
AU  - Wang C
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Zhou, Wenhua
AU  - Zhou W
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Wang, Qinwen
AU  - Wang Q
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Chen, Xiaowei
AU  - Chen X
AD  - Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key 
      Laboratory of Pathophysiology, The Medical School of Ningbo University, Ningbo 
      University, Ningbo, China.
FAU - Chen, Junping
AU  - Chen J
AD  - Department of Anesthesiology, Ningbo No. 2 Hospital, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20180523
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5974208
OTO - NOTNLM
OT  - P2X4
OT  - fast green FCF
OT  - inflammation
OT  - inflammatory pain
OT  - interleukin
OT  - pro-inflammatory cytokines
OT  - tumor necrosis factor
EDAT- 2018/06/08 06:00
MHDA- 2018/06/08 06:01
PMCR- 2018/05/23
CRDT- 2018/06/08 06:00
PHST- 2017/11/10 00:00 [received]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2018/06/08 06:01 [medline]
PHST- 2018/05/23 00:00 [pmc-release]
AID - 10.3389/fphar.2018.00534 [doi]
PST - epublish
SO  - Front Pharmacol. 2018 May 23;9:534. doi: 10.3389/fphar.2018.00534. eCollection 
      2018.