PMID- 29875964
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20181114
IS  - 1937-8688 (Electronic)
VI  - 29
DP  - 2018
TI  - Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
PG  - 83
LID - 10.11604/pamj.2018.29.83.10595 [doi]
LID - 83
AB  - Paracetamol is the most widely drug involved in accidental paediatric exposures 
      and deliberate self-poisoning cases because of its availability. N-acetyl cystein 
      is the main treatment for this poisoning. We report a case of a 24-year-old Arab 
      female who has deliberately ingested 100 tablets of 500 mg paracetamol each 
      (50g). Her first examination was normal. She has received oral N-acetyl cystein 
      (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post 
      ingestion was 900 mg/l. On review the next days, she did not develop any symptoms 
      of liver failure. However, due to the massive paracetamol ingestion associated 
      with high serum paracetamol levels, oral NAC was continued for 3 days. The 
      patient was discharged well on the fifth day of hospitalization. Our patient has 
      ingested one of the highest paracetamol overdose (50g) with the highest 
      paracetamol blood levels ever reported in medical literature. She was treated, 
      six hours after ingestion, with oral NAC for 3 days without any side effects.
FAU - Benlamkaddem, Said
AU  - Benlamkaddem S
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
FAU - Iken, Imane
AU  - Iken I
AD  - Laboratory of toxicology, Hassan II University Hospital, Fez, Morocco.
FAU - Houari, Nawfal
AU  - Houari N
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
FAU - Elbouazzaoui, Abderrahim
AU  - Elbouazzaoui A
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
FAU - Boukatta, Brahim
AU  - Boukatta B
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
FAU - Sbai, Hicham
AU  - Sbai H
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
FAU - Achour, Sanae
AU  - Achour S
AD  - Laboratory of toxicology, Hassan II University Hospital, Fez, Morocco.
FAU - Kanjaa, Nabil
AU  - Kanjaa N
AD  - Intensive Care Unit, Hassan II University Hospital, Fez, Morocco.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180129
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Antidotes)
RN  - 0 (Tablets)
RN  - 362O9ITL9D (Acetaminophen)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetaminophen/pharmacokinetics/*poisoning
MH  - Acetylcysteine/*administration & dosage
MH  - Administration, Oral
MH  - Antidotes/*administration & dosage
MH  - Drug Overdose
MH  - Female
MH  - Humans
MH  - Suicide, Attempted
MH  - Tablets
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5987070
OTO - NOTNLM
OT  - N-acetyl cystein
OT  - Paracetamol self-poisoning
OT  - Rumack-Mathew Nomogram
OT  - case report
OT  - liver failure
OT  - paracetamol serum concentration
EDAT- 2018/06/08 06:00
MHDA- 2018/06/15 06:00
PMCR- 2018/01/29
CRDT- 2018/06/08 06:00
PHST- 2016/08/25 00:00 [received]
PHST- 2017/11/14 00:00 [accepted]
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
PHST- 2018/01/29 00:00 [pmc-release]
AID - PAMJ-29-83 [pii]
AID - 10.11604/pamj.2018.29.83.10595 [doi]
PST - epublish
SO  - Pan Afr Med J. 2018 Jan 29;29:83. doi: 10.11604/pamj.2018.29.83.10595. 
      eCollection 2018.