PMID- 29877065
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 65
IP  - 6
DP  - 2018 Dec
TI  - A comparison of the severity of reproductive failure between single and dual 
      infection with porcine reproductive and respiratory syndrome virus (PRRSV)-1 and 
      PRRSV-2 in late-term pregnancy gilts.
PG  - 1641-1647
LID - 10.1111/tbed.12921 [doi]
AB  - The objective of this study was to compare the severity of reproductive failure 
      caused by either a single or a dual infection with porcine reproductive and 
      respiratory syndrome virus (PRRSV)-1 and PRRSV-2 in late-term pregnancy gilts. 
      Pregnant gilts were intranasally administered PRRSV-1, PRRSV-2 or both at 3 weeks 
      before the expected farrowing date (93 days of gestation). Regardless of single 
      and dual infection, PRRSV-infected pregnant gilts experienced premature farrowing 
      (103-109 days of gestation) compared with negative control gilts which carried 
      their pregnancy to full term (114-115 days of gestation). Pregnant gilts infected 
      with only PRRSV-1 had a significantly (p < 0.05) higher number of genomic copies 
      of PRRSV-1 in their blood compared with dually infected gilts. Additionally, 
      stillborn foetuses and live-born piglets from pregnant gilts infected with only 
      PRRSV-1 had a significantly (p < 0.05) higher number of PRRSV-1-positive cells 
      per unit area of tissue sections examined, compared to pregnant gilts dually 
      infected with PRRSV-1 and PRRSV-2. In contrast, pregnant gilts infected with only 
      PRRSV-2 showed no difference in the number of genomic copies of PRRSV-2 compared 
      with dually infected pregnant gilts and there were no significant differences in 
      PRRSV-2-positive cells per unit area in tissues of stillborn foetuses and 
      live-born piglets from pregnant gilts infected with PRRSV-2 only compared with 
      dually infected gilts. Interestingly, even though PRRSV-2 was shown to replicate 
      more efficiently compared with PRRSV-1 in dually infected pregnant gilts, neither 
      PRRSV type was able to exacerbate reproductive failure in pregnant gilts already 
      dually infected with PRRSV-1 and PRRSV-2. Our results suggest that the severity 
      of reproductive failure is similar between dual (PRRSV-1 and PRRSV-2) and single 
      infection (PRRSV-1 or PRRSV-2).
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kim, Seeun
AU  - Kim S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Yoon, Jai Soon
AU  - Yoon JS
AD  - CJ Cheiljedang Center, CJ CHEILJEDANG, Seoul, Korea.
FAU - Lee, Ohhyung
AU  - Lee O
AD  - CJ Cheiljedang Center, CJ CHEILJEDANG, Seoul, Korea.
FAU - Chae, Chanhee
AU  - Chae C
AUID- ORCID: 0000-0002-0190-1957
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
LA  - eng
GR  - 5260-20150100/BK 21 Plus Program for Creative Veterinary Science Research/
GR  - 550-20160013/CJ CHEILJEDANG/
PT  - Comparative Study
PT  - Journal Article
DEP - 20180607
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
SB  - IM
MH  - Administration, Intranasal
MH  - Animals
MH  - Female
MH  - Fetal Death
MH  - Fetus/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology/virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/isolation & 
      purification/*pathogenicity
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*veterinary/virology
MH  - *Pregnancy, Animal
MH  - Stillbirth
MH  - Sus scrofa
MH  - Swine
OTO - NOTNLM
OT  - coinfection
OT  - porcine reproductive and respiratory syndrome virus
OT  - reproductive failure
OT  - sow
EDAT- 2018/06/08 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/06/08 06:00
PHST- 2018/02/08 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/11 00:00 [accepted]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/06/08 06:00 [entrez]
AID - 10.1111/tbed.12921 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2018 Dec;65(6):1641-1647. doi: 10.1111/tbed.12921. Epub 
      2018 Jun 7.