PMID- 29877741
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 43
IP  - 9
DP  - 2018 Sep
TI  - Association between Serum Immnunoglobulin E and Pterygium: A Population-Based 
      Study from South Korea.
PG  - 1090-1096
LID - 10.1080/02713683.2018.1484145 [doi]
AB  - PURPOSE: Several studies have shown that pterygium is associated with 
      inflammation, angiogenesis, and fibrosis. However, it should be acknowledged that 
      not enough is known about the association between immunoglobulin E (IgE) and 
      pterygium. The present study was conducted to test the hypothesis that elevated 
      serum IgE is associated with a greater prevalence of pterygium. MATERIAL AND 
      METHODS: A cross-sectional study was performed using data of 1,548 participants 
      aged 30 years or older who were enrolled in the Korea National Health and 
      Nutrition Examination Survey conducted in 2010. Multivariable logistic regression 
      analysis was used to examine the relationship between pterygium and allergic 
      conditions, including total serum IgE and allergen-specific serum IgE levels, 
      after adjusting for potential confounding factors. RESULTS: Participants with 
      pterygium were more likely have increased IgE level (p = 0.009). After adjusting 
      for potential confounders, the odds ratio (OR) for pterygium was greater in 
      participants with higher total serum IgE levels (OR = 1.63; p = 0.047). 
      Multivariable-adjusted ORs of pterygium across the tertile of increasing IgE were 
      1.00 (reference), 1.18, and 1.45, (P for linear trend = 0.038). Although the ORs 
      for the upper two tertiles of cockroach and dog allergen-specific IgE were higher 
      than those for the lowest tertile, allergen-specific serum IgE showed no clear 
      association with pterygium. CONCLUSIONS: Increased total serum IgE concentration 
      is independently related to pterygium after adjusting for confounding factors. To 
      the best of our knowledge, this study is the first research that reveals an 
      association between serum IgE and pterygium.
FAU - Yoo, Tae Keun
AU  - Yoo TK
AUID- ORCID: 0000-0003-0890-8614
AD  - a Institute of Vision Research, Department of Ophthalmology , Yonsei University 
      College of Medicine , Seoul , South Korea.
FAU - Kim, Sun Woong
AU  - Kim SW
AD  - b Department of Ophthalmology , Yonsei University Wonju College of Medicine , 
      Wonju , South Korea.
FAU - Seo, Kyoung Yul
AU  - Seo KY
AD  - a Institute of Vision Research, Department of Ophthalmology , Yonsei University 
      College of Medicine , Seoul , South Korea.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180709
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Nutrition Surveys
MH  - Odds Ratio
MH  - Prevalence
MH  - Pterygium/*blood/diagnosis/epidemiology
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Slit Lamp Microscopy
OTO - NOTNLM
OT  - Pterygium
OT  - South Korea
OT  - allergy
OT  - immunoglobulin E
OT  - inflammation
EDAT- 2018/06/08 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/06/08 06:00
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/06/08 06:00 [entrez]
AID - 10.1080/02713683.2018.1484145 [doi]
PST - ppublish
SO  - Curr Eye Res. 2018 Sep;43(9):1090-1096. doi: 10.1080/02713683.2018.1484145. Epub 
      2018 Jul 9.