PMID- 29879390
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 98
IP  - 5
DP  - 2018 Jun 6
TI  - Overcoming Depression by Inhibition of Neural Burst Firing.
PG  - 878-879
LID - S0896-6273(18)30430-6 [pii]
LID - 10.1016/j.neuron.2018.05.032 [doi]
AB  - The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to 
      have rapid and long-lasting antidepressive effects. Two elegant studies from 
      Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine 
      blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving 
      symptoms of depression.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Kim, Daesoo
AU  - Kim D
AD  - Department of Biological Sciences, Korea Advanced Institute of Science & 
      Technology (KAIST), Daejeon 34141, Republic of Korea. Electronic address: 
      daesoo@kaist.ac.kr.
FAU - Cheong, Eunji
AU  - Cheong E
AD  - Department of Biotechnology, College of Life Science and Biotechnology, Yonsei 
      University, Seoul 03722, Republic of Korea. Electronic address: 
      eunjicheong@yonsei.ac.kr.
FAU - Shin, Hee-Sup
AU  - Shin HS
AD  - Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 
      34141, Republic of Korea. Electronic address: shin@ibs.re.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Calcium Channels, T-Type)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Kcnj10 (channel))
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
MH  - Anhedonia/drug effects
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Calcium Channels, T-Type/metabolism
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Excitatory Amino Acid Antagonists/*pharmacology/therapeutic use
MH  - Habenula/cytology/*drug effects/metabolism
MH  - Helplessness, Learned
MH  - Ketamine/*pharmacology/therapeutic use
MH  - Neurons/*drug effects/metabolism
MH  - Potassium Channels, Inwardly Rectifying/metabolism
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
MH  - Restraint, Physical
EDAT- 2018/06/08 06:00
MHDA- 2019/08/06 06:00
CRDT- 2018/06/08 06:00
PHST- 2018/06/08 06:00 [entrez]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
AID - S0896-6273(18)30430-6 [pii]
AID - 10.1016/j.neuron.2018.05.032 [doi]
PST - ppublish
SO  - Neuron. 2018 Jun 6;98(5):878-879. doi: 10.1016/j.neuron.2018.05.032.