PMID- 29879658
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 61
DP  - 2018 Aug
TI  - A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL 
      induced NFATc-1/c-Fos induction.
PG  - 150-155
LID - S1567-5769(18)30247-9 [pii]
LID - 10.1016/j.intimp.2018.05.030 [doi]
AB  - Function studies of pectolinarigenin demonstrated that, as a natural product, it 
      possesses the regulatory effects on transcription factors (TFs) such as: signal 
      transducer and activator of transcription 3 (STAT3). Herein, we aimed to identify 
      the regulatroy effects of pectolinarigenin on the osteoclastogenesis TFs such as: 
      NFATc1 and c-Fos, and further identify the relevant up-stream signals activity. 
      We initially found pectolinarigenin inhibited receptor activator of nuclear 
      factor-kappa B ligand (RANKL) induced osteoclast formation during the bone 
      marrow-derived macrophages (BMMs) cultures, suggesting that this natural product 
      could act on osteoclast precursors by inhibiting the down signaling cascades of 
      RANKL signaling. Moreover, mechanistical investigation showed pectolinarigenin 
      inhibits RANKL-mediated osteoclastogenesis by attenuating the nuclear factor of 
      activated T cells cytoplasmic 1 (NFATc-1) and c-Fos following the Akt and mitogen 
      activated protein kinases (MAPKs) signaling costimulatory. These findings 
      identify that pectolinarigenin may act as an anti-resorption agent by blocking 
      osteoclast activation.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Zhang, Ke
AU  - Zhang K
AD  - Yan'an University Medical School, Yan'an, China.
FAU - Lei, Jun
AU  - Lei J
AD  - Gaoling Orthopaedic Hospital, Xi'an, China.
FAU - He, Yuan
AU  - He Y
AD  - Xi'an Medical University, Xi'an, China.
FAU - Yang, Xiaobin
AU  - Yang X
AD  - Department of Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, Xi'an, China.
FAU - Zhang, Zhen
AU  - Zhang Z
AD  - Department of Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, Xi'an, China.
FAU - Hao, Dingjun
AU  - Hao D
AD  - Department of Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, Xi'an, China. Electronic address: dhao.honghui@outlook.com.
FAU - Wang, Biao
AU  - Wang B
AD  - Department of Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, Xi'an, China. Electronic address: honghui.jtu@medcenter.net.cn.
FAU - He, Baorong
AU  - He B
AD  - Department of Spine Surgery, Hong-Hui Hospital, Xi'an Jiaotong University College 
      of Medicine, Xi'an, China. Electronic address: hbr_jtu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180604
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Chromones)
RN  - 0 (Flavanones)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Nfatc1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RANK Ligand)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (pectolinarigenin)
RN  - WX22P730FB (flavanone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Bone Marrow Cells/cytology
MH  - Bone Resorption/*drug therapy
MH  - Cells, Cultured
MH  - Chromones/chemistry/*pharmacology
MH  - Flavanones/chemistry
MH  - Humans
MH  - Macrophages/*drug effects/physiology
MH  - Mice
MH  - NFATC Transcription Factors/metabolism
MH  - Osteoclasts/*drug effects/physiology
MH  - Osteogenesis
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - RANK Ligand/metabolism
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - BMMs
OT  - MAPKs
OT  - NFATc1;c-Fos
OT  - Pectolinarigenin
OT  - Signaling pathway
EDAT- 2018/06/08 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/06/08 06:00
PHST- 2018/01/20 00:00 [received]
PHST- 2018/05/27 00:00 [revised]
PHST- 2018/05/29 00:00 [accepted]
PHST- 2018/06/08 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/06/08 06:00 [entrez]
AID - S1567-5769(18)30247-9 [pii]
AID - 10.1016/j.intimp.2018.05.030 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2018 Aug;61:150-155. doi: 10.1016/j.intimp.2018.05.030. Epub 
      2018 Jun 4.