PMID- 29879817
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 1011-2367 (Print)
IS  - 1011-2367 (Linking)
DP  - 2018 May 31
TI  - WITHDRAWN:Hematological and vasodilator characteristics for high altitude 
      acclimatization in Holstein heifers ascended to high altitude.
LID - 10.5713/ajas.18.0224 [doi]
AB  - OBJECTIVE: This study was conducted to investigate hematological and vasodilator 
      characteristics for high altitude acclimatization in Holstein heifers ascended to 
      high altitude. METHODS: Holstein heifers resided at low altitude (LH; Beijing, 
      China 43 meter), and Holstein heifers ascended to high altitude (Lhasa city, 
      Tibet; 3,658 meter) after one year exposure including hypoxia acclimated Holstein 
      heifers (AH; with mean pulmonary arterial pressure mPAP < 41 mmHg) and Holstein 
      heifers affected by high altitude pulmonary hypertension (HAPH; with mPAP > 49 
      mmHg) and crossbred cattle (CB; Holstein x Tibet cattle) born and resided in 
      Tibet were selected to compare parameters of blood gas, blood cells and 
      vasodilators. Each group included 15 animals with 16 to 18 month of age. RESULTS: 
      The HAPH had greater mPAP than other cattle classes (P < 0.01). Alveolar 
      ventilation (as indicated by partial pressure of carbon dioxide; PaCO2) was 
      improved in AH and HAPH compared to LH, but it was lower in HAPH than in CB and 
      AH (P < 0.05). In addition, LH had the greatest and HAPH had the lowest partial 
      pressure of oxygen (PaO2) among the four cattle classes (P < 0.05). 
      Erythropoietin and mean corpuscular hemoglobin concentration were greater in AH 
      and HAPH than LH (P < 0.05). Serum iron was greater in AH than LA and HAPH (P < 
      0.05). Hypoxia exposure increased plasma nitric oxide and endothelin-1 in cattle 
      resided in Tibet compared to LH. Additionally, AH had greater brain natriuretic 
      peptides than HAPH and LH, and AH had greatest C-type natriuretic peptides than 
      the other groups (P < 0.05). CONCLUSION: High altitude hypoxia acclimatization 
      was achieved in Holstein heifers ascended to high altitude via augmented alveolar 
      ventilation, serum iron, mean corpuscular hemoglobin concentration, natriuretic 
      peptides and nitric oxide, it enables them to tolerate the high altitude.
FAU - Wang, Shuxiang
AU  - Wang S
AD  - State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research 
      Center of Raw Milk Quality and Safety Control, College of Animal Science and 
      Technology, Beijing, China.
FAU - Azarfar, Arash
AU  - Azarfar A
AD  - Faculty of Agriculture, Department of Animal Science, Lorestan University, 
      Beijing, China.
FAU - Wang, YaJing
AU  - Wang Y
AD  - State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research 
      Center of Raw Milk Quality and Safety Control, College of Animal Science and 
      Technology, Beijing, China.
FAU - Cao, Zhijun
AU  - Cao Z
AD  - State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research 
      Center of Raw Milk Quality and Safety Control, College of Animal Science and 
      Technology, Beijing, China.
FAU - Shi, Quangui
AU  - Shi Q
AD  - Clinical Laboratory, General Hospital of Tibet Military Command, Lhasa, 850003, 
      P. R. China., Lhasa, China.
FAU - Li, Shengli
AU  - Li S
AD  - Faculty of Agriculture, Department of Animal Science, Lorestan University, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20180531
PL  - Korea (South)
TA  - Asian-Australas J Anim Sci
JT  - Asian-Australasian journal of animal sciences
JID - 9884245
OTO - NOTNLM
OT  - Hemodynamics
OT  - Holstein
OT  - Hypoxia
OT  - Vasodilators
EDAT- 2018/06/09 06:00
MHDA- 2018/06/09 06:01
CRDT- 2018/06/09 06:00
PHST- 2018/03/16 00:00 [received]
PHST- 2018/05/24 00:00 [accepted]
PHST- 2018/06/09 06:00 [entrez]
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2018/06/09 06:01 [medline]
AID - ajas.18.0224 [pii]
AID - 10.5713/ajas.18.0224 [doi]
PST - aheadofprint
SO  - Asian-Australas J Anim Sci. 2018 May 31. doi: 10.5713/ajas.18.0224.