PMID- 29880078
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 45
IP  - 4
DP  - 2018 Jul
TI  - Biological and Behavioral Patterns of Post-Stroke Depression in Rats.
PG  - 451-461
LID - 10.1017/cjn.2017.302 [doi]
AB  - BACKGROUND: Post-stroke depression (PSD) is the most frequent psychiatric 
      complication following ischemic stroke. It affects up to 60% of all patients and 
      is associated with increased morbidity and mortality following ischemic stroke. 
      The pathophysiology of PSD remains elusive and appears to be multifactorial, 
      rather than "purely" biological or psychosocial in origin. Thus, valid animal 
      models of PSD would contribute to the study of the etiology (and treatment) of 
      this disorder. METHODS: The present study depicts a rat model for PSD, using 
      middle cerebral artery occlusion (MCAO). The two-way shuttle avoidance task, 
      Porsolt forced-swim test, and sucrose preference test were employed to assess any 
      depression-like behavior. Localized brain expressions of brain-derived 
      neurotrophic factor (BDNF) protein levels were evaluated to examine the possible 
      involvement of the brain neuronal plasticity in the observed behavioral syndrome. 
      The raw data were subjected to unsupervised fuzzy clustering (UFC) algorithms to 
      assess the sensitivity of bio-behavioral measures indicative of depressive 
      symptoms post MCAO. RESULTS: About 56% of the rats developed significant 
      depressive-like behavioral disruptions as a result of MCAO compared with 4% in 
      the sham-operated control rats. A pattern of a depressive-like behavioral 
      response was common to all affected MCAO animals, characterized by significantly 
      more escape failures and reduced number of total avoidance shuttles, a 
      significant elevation in immobility duration, and reduced sucrose preference. 
      Significant downregulations of BDNF protein levels in the hippocampal 
      sub-regions, frontal cortex, and hypothalamus were observed in all affected MCAO 
      animals. CONCLUSION: The UFC analysis supports the behavioral analysis and thus, 
      lends validity to our results.
FAU - Ifergane, Gal
AU  - Ifergane G
AD  - 1Department of Neurology,Soroka Medical Center,Ben-Gurion University of the 
      Negev,Beer-Sheva,Israel.
FAU - Boyko, Matthew
AU  - Boyko M
AD  - 2Division of Anesthesiology and Critical Care,Soroka Medical Center,Ben-Gurion 
      University of the Negev,Beer-Sheva,Israel.
FAU - Frank, Dmitri
AU  - Frank D
AD  - 2Division of Anesthesiology and Critical Care,Soroka Medical Center,Ben-Gurion 
      University of the Negev,Beer-Sheva,Israel.
FAU - Shiyntum, Honore N
AU  - Shiyntum HN
AD  - 3Department of Biophysics and Biochemistry,Oles' Honchar Dnipro National 
      University,Dnipro,Ukraine.
FAU - Grinshpun, Julia
AU  - Grinshpun J
AD  - 2Division of Anesthesiology and Critical Care,Soroka Medical Center,Ben-Gurion 
      University of the Negev,Beer-Sheva,Israel.
FAU - Kuts, Ruslan
AU  - Kuts R
AD  - 2Division of Anesthesiology and Critical Care,Soroka Medical Center,Ben-Gurion 
      University of the Negev,Beer-Sheva,Israel.
FAU - Geva, Amir B
AU  - Geva AB
AD  - 4Department of Electrical and Computer Engineering,Ben-Gurion University of the 
      Negev,Beer-Sheva,Israel.
FAU - Kaplan, Zeev
AU  - Kaplan Z
AD  - 5Beer-Sheva Mental Health Center,The State of Israel Ministry of Health, Anxiety, 
      and Stress Research Unit, Faculty of Health Sciences,Ben-Gurion University of the 
      Negev,Beer-Sheva,Israel.
FAU - Zeldetz, Vladimir
AU  - Zeldetz V
AD  - 6Department of Emergent Medicine,Soroka University Medical Center,Ben-Gurion 
      University of the Negev,Beer-Sheva,Israel.
FAU - Cohen, Hagit
AU  - Cohen H
AD  - 5Beer-Sheva Mental Health Center,The State of Israel Ministry of Health, Anxiety, 
      and Stress Research Unit, Faculty of Health Sciences,Ben-Gurion University of the 
      Negev,Beer-Sheva,Israel.
LA  - eng
PT  - Journal Article
DEP - 20180608
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Brain/metabolism
MH  - Brain Infarction/etiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cluster Analysis
MH  - Depression/etiology/*metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/*physiology
MH  - Food Preferences/psychology
MH  - Infarction, Middle Cerebral Artery/complications/pathology
MH  - Male
MH  - Neurologic Examination
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Statistics, Nonparametric
MH  - Sucrose/administration & dosage
MH  - Swimming/psychology
OTO - NOTNLM
OT  - Animal model
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Middle cerebral artery occlusion (MCAO)
OT  - Post-stroke depression (PSD)
EDAT- 2018/06/09 06:00
MHDA- 2019/03/06 06:00
CRDT- 2018/06/09 06:00
PHST- 2018/06/09 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2018/06/09 06:00 [entrez]
AID - S031716711700302X [pii]
AID - 10.1017/cjn.2017.302 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2018 Jul;45(4):451-461. doi: 10.1017/cjn.2017.302. Epub 2018 
      Jun 8.